{"id":"W2064388013","doi":"10.1371/journal.pone.0027799","title":"Generation of Immortal Cell Lines from the Adult Pituitary: Role of cAMP on Differentiation of SOX2-Expressing Progenitor Cells to Mature Gonadotropes","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University Health Network; University of Toronto","funders":"Canadian Institutes of Health Research; University of California, San Diego; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Biology; Progenitor cell; SOX2; Gonadotropic cell; Cellular differentiation; Cell biology; Internal medicine; Cell culture; Endocrinology; Stem cell; Pituitary gland; Hormone; Transcription factor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002954891,0.0002710957,0.0002971298,0.0003433768,0.0002540689,0.0003754663,0.00026509,0.0001742238,0.001963245],"category_scores_gemma":[0.0002051381,0.0002189123,0.0003068665,0.000225506,0.0002229739,0.0001974285,0.0002627842,0.0007108661,0.001147469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001569964,"about_ca_system_score_gemma":0.0002714544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004961165,"about_ca_topic_score_gemma":0.001009921,"domain_scores_codex":[0.99977,0.00001855741,0.00004541494,0.00004237,0.00008432775,0.00003929511],"domain_scores_gemma":[0.9997064,0.00005896709,0.00004676944,0.00006685824,0.00005101279,0.00006999677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004183548,0.0000245826,0.0002624136,0.00001988614,0.000003204976,0.00007761466,0.00006020295,0.00001831167,0.9985367,0.00008983105,0.00005183794,0.0008136294],"study_design_scores_gemma":[0.00002330561,0.0001749286,0.004456094,0.00000967764,0.00002500865,0.0005575741,0.00006810191,0.0006809279,0.9841962,0.00005039693,0.009750802,0.000006967167],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9643788,0.001282137,0.02678211,0.0001569317,0.0001524246,0.0003794183,0.002853354,0.0002694647,0.00374526],"genre_scores_gemma":[0.9379232,0.003076764,0.03393111,0.0001576251,0.00009079139,0.000599422,0.008296235,0.0002934619,0.01563136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001963245,"threshold_uncertainty_score":0.006567776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03602895765751131,"score_gpt":0.2252728500295641,"score_spread":0.1892438923720527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}