{"id":"W2064388215","doi":"10.1007/s40429-014-0033-8","title":"Translating Neurobiology to the Treatment of Dual Diagnosis: The Example of Nicotinic Receptors and Neurocognitive Endophenotypes in Schizophrenia","year":2014,"lang":"en","type":"article","venue":"Current Addiction Reports","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Addiction and Mental Health; University of Toronto","funders":"","keywords":"Endophenotype; Neurocognitive; Schizophrenia (object-oriented programming); Sensory gating; Psychology; Psychiatry; Psychosis; Nicotinic agonist; Neuroscience; Gating; Cognition; Clinical psychology; Medicine; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001381263,0.0003139772,0.0005448685,0.0004936478,0.0004328158,0.001421915,0.0003635847,0.0008550407,0.001659548],"category_scores_gemma":[0.003458021,0.0001261098,0.0003642177,0.0003661535,0.001384701,0.0007996838,0.000787035,0.001643372,0.0001339741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001397305,"about_ca_system_score_gemma":0.00225247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003690731,"about_ca_topic_score_gemma":0.007491705,"domain_scores_codex":[0.999603,0.0002191159,0.00002513983,0.00003522925,0.00007919856,0.00003832284],"domain_scores_gemma":[0.9992366,0.0004332071,0.0001082463,0.00005396998,0.00009748871,0.00007059018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.003469868,0.001524844,0.09965146,0.001310668,0.0007555833,0.00384435,0.00244128,0.002300112,0.0369828,0.09050306,0.01021203,0.747004],"study_design_scores_gemma":[0.001466788,0.0040644,0.4119581,0.00327324,0.001361836,0.005665625,0.008866239,0.005198957,0.01727277,0.4721852,0.06841727,0.0002695585],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.6892493,0.1100536,0.009942241,0.1533612,0.001617227,0.0001086074,0.0004939295,0.0001096894,0.03506416],"genre_scores_gemma":[0.9462327,0.04194295,0.003558518,0.006067369,0.0005722115,0.00003978227,0.00006839196,0.00002395153,0.001494042],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.003690731,"threshold_uncertainty_score":0.01013827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01734071189550625,"score_gpt":0.2684056246996421,"score_spread":0.2510649128041359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}