{"id":"W2064411615","doi":"10.2147/tacg.s10604","title":"Alpha1-antitrypsin deficiency: a clinical-genetic overview","year":2011,"lang":"en","type":"article","venue":"The Application of Clinical Genetics","topic":"Chronic Obstructive Pulmonary Disease (COPD) Research","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; Children's & Women's Health Centre of British Columbia; University of British Columbia","funders":"","keywords":"Alpha 1-antitrypsin deficiency; Medicine; Allele; Liver disease; Disease; Genetic disorder; Hepatitis; Genotype; Gastroenterology; Internal medicine; Immunology; Pathology; Gene; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001924466,0.0001944774,0.0006767913,0.00005794959,0.00007927306,0.00000816064,0.0006751945,0.0002199357,0.0004718871],"category_scores_gemma":[0.0005866255,0.0001396788,0.0004851166,0.0004484699,0.001126777,0.00002560951,0.0002740414,0.0004702525,0.0004597572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002787826,"about_ca_system_score_gemma":0.0004969339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005140238,"about_ca_topic_score_gemma":0.00000758317,"domain_scores_codex":[0.996161,0.0003861526,0.001909213,0.0005693796,0.0006253601,0.0003489171],"domain_scores_gemma":[0.9962148,0.0006503687,0.0005559402,0.001795096,0.0004263375,0.0003574719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0004795752,0.002016877,0.4780551,0.0003319663,0.0001458688,0.000008413364,0.00009526157,0.000007808664,0.0002184606,0.00493542,0.001751994,0.5119532],"study_design_scores_gemma":[0.001238895,0.0003590556,0.9659204,0.00003951587,0.0003074775,0.00001449424,0.00005071222,0.002160231,0.0003322971,0.006371877,0.02306414,0.0001409367],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9557935,0.01714941,0.006743888,0.001015575,0.0002692286,0.002026473,0.00003361459,0.00007491955,0.0168934],"genre_scores_gemma":[0.9818991,0.006112494,0.01040739,0.0007110103,0.0003487596,0.00007935015,0.00001468124,0.00004154105,0.0003857107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5118123,"threshold_uncertainty_score":0.5909402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1887380778619873,"score_gpt":0.4550121470766242,"score_spread":0.2662740692146368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}