{"id":"W2064415817","doi":"10.1073/pnas.1013012108","title":"Sulfiredoxin–Peroxiredoxin IV axis promotes human lung cancer progression through modulation of specific phosphokinase signaling","year":2011,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Redox biology and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health; University of South Carolina","keywords":"Gene knockdown; Carcinogenesis; Oxidative stress; Peroxiredoxin; Cell biology; Cancer research; Metastasis; Signal transduction; Biology; DNA damage; Cancer cell; Tumor progression; Cancer; Chemistry; Apoptosis; Biochemistry; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005667569,0.000114158,0.0001520836,0.00005485662,0.0001817802,0.000006327471,0.0005286104,0.0001551193,0.0000321219],"category_scores_gemma":[0.0001123334,0.0000765355,0.00008518199,0.000295426,0.001040287,0.00004331455,0.0001383304,0.00009340816,1.390307e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001245049,"about_ca_system_score_gemma":0.00003244942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001544006,"about_ca_topic_score_gemma":1.77829e-7,"domain_scores_codex":[0.998782,0.00001399858,0.0003382691,0.0003014854,0.0004203749,0.0001438171],"domain_scores_gemma":[0.9990559,0.00001488043,0.0005648485,0.00001652517,0.0003261621,0.00002163633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005312762,0.0000716674,0.03826683,0.00005538825,0.00002633439,5.536453e-9,0.0002736076,0.00002130092,0.955336,0.005371111,0.000156469,0.0003681771],"study_design_scores_gemma":[0.0001650494,0.0001223991,0.07224581,0.0001358492,0.000009479535,0.000001428153,0.00009272255,0.0001111137,0.9210312,0.005943974,0.00005921179,0.00008176702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962764,0.00101345,0.000009738506,0.0001244056,0.00002319249,0.0002348812,0.00002354646,0.000004492304,0.002289891],"genre_scores_gemma":[0.9972156,0.0001256222,0.002467925,0.00002844402,0.00007771929,0.00001972856,0.00000188491,0.000005188977,0.00005785744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03430479,"threshold_uncertainty_score":0.3832981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05369003264784081,"score_gpt":0.3392342619973744,"score_spread":0.2855442293495336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}