{"id":"W2064431167","doi":"10.1056/nejmoa0904452","title":"Rituximab, B-Lymphocyte Depletion, and Preservation of Beta-Cell Function","year":2009,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1073,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Genentech; National Institutes of Health; MacroGenics; American Diabetes Association; Osiris Therapeutics; Biogen; Eli Lilly and Company; Juvenile Diabetes Research Foundation International","keywords":"Medicine; Rituximab; Glycated hemoglobin; Internal medicine; Placebo; Gastroenterology; Lymphocyte; Diabetes mellitus; Immunology; CD20; Type 1 diabetes; Type 2 diabetes; Endocrinology; Lymphoma; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003189492,0.00006516281,0.0001681131,0.00004553193,0.00002002562,0.000003851759,0.00005287418,0.00005644705,0.00001712681],"category_scores_gemma":[0.00009956101,0.00004753875,0.00003318479,0.00005495908,0.00002848269,0.00000774867,0.00000714868,0.00005631948,2.709417e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005592419,"about_ca_system_score_gemma":0.00004717229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000017556,"about_ca_topic_score_gemma":0.000007408161,"domain_scores_codex":[0.9994307,0.00003314558,0.0002467183,0.00006857305,0.0001414568,0.00007946904],"domain_scores_gemma":[0.9994668,0.00001435558,0.0002424799,0.00006468791,0.0001404136,0.00007125879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001096842,0.000249808,0.02612954,0.00003959277,0.0001354305,0.000003541475,0.0002819976,0.0001308865,0.6348943,0.00017032,0.02935058,0.3075172],"study_design_scores_gemma":[0.1838979,0.01754303,0.1882036,0.000350952,0.0006568698,0.0001092863,0.0004693611,0.0001782948,0.09231938,0.006027034,0.5098416,0.0004027466],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880466,0.007092969,0.001475262,0.002271165,0.0001407436,0.00004110043,0.000001237595,0.000001794466,0.0009290522],"genre_scores_gemma":[0.9969404,0.001492191,0.0001606424,0.0003799401,0.0007402289,1.473918e-7,0.00001733099,0.000004194275,0.0002648664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5425749,"threshold_uncertainty_score":0.1938574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006280397877447326,"score_gpt":0.2181026816178047,"score_spread":0.2118222837403574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}