{"id":"W2064431167","doi":"10.1056/nejmoa0904452","title":"Rituximab, B-Lymphocyte Depletion, and Preservation of Beta-Cell Function","year":2009,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1073,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Genentech; National Institutes of Health; MacroGenics; American Diabetes Association; Osiris Therapeutics; Biogen; Eli Lilly and Company; Juvenile Diabetes Research Foundation International","keywords":"Medicine; Rituximab; Glycated hemoglobin; Internal medicine; Placebo; Gastroenterology; Lymphocyte; Diabetes mellitus; Immunology; CD20; Type 1 diabetes; Type 2 diabetes; Endocrinology; Lymphoma; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00213934,0.0004299527,0.001024,0.000321462,0.0001659604,0.0003493009,0.0004084255,0.0006551385,0.0009846536],"category_scores_gemma":[0.00146693,0.0002102805,0.0005039059,0.0001995909,0.0004179876,0.0002872011,0.0002286457,0.0007436264,0.0001307769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002995221,"about_ca_system_score_gemma":0.0004660817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001266793,"about_ca_topic_score_gemma":0.000283197,"domain_scores_codex":[0.9991178,0.0005527679,0.00006318862,0.00008080582,0.00010846,0.00007691069],"domain_scores_gemma":[0.9986975,0.0006458613,0.0003724594,0.00005055001,0.00004108389,0.0001926402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.4676572,0.0203572,0.0235385,0.002378019,0.002073318,0.0006033271,0.0001602005,0.001514775,0.03430801,0.0005043044,0.001903001,0.4450022],"study_design_scores_gemma":[0.2847338,0.6213015,0.06500462,0.000459997,0.001539416,0.002697779,0.00007335744,0.001546539,0.01442756,0.0006732178,0.007494015,0.00004819141],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9675726,0.03038552,0.0004288026,0.0003307959,0.00007527898,0.0002261282,0.00004128147,0.00001989017,0.0009195344],"genre_scores_gemma":[0.9923551,0.005539587,0.0008530625,0.0004769413,0.0001816181,0.0002726925,0.00009507265,0.000004418269,0.0002214785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00213934,"threshold_uncertainty_score":0.01131409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006280397877447326,"score_gpt":0.2181026816178047,"score_spread":0.2118222837403574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}