{"id":"W2064450689","doi":"10.1074/jbc.m302676200","title":"Structure-guided Protein Engineering Modulates Helix Bundle Exchangeable Apolipoprotein Properties","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Helix bundle; Helix (gastropod); Bundle; Apolipoprotein B; Chemistry; Protein structure; Materials science; Biology; Biochemistry; Cholesterol; Composite material","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002334361,0.0002610335,0.0003162705,0.00002765471,0.00006301455,0.00003716873,0.0003005731,0.0004025782,0.0001006086],"category_scores_gemma":[0.0005808107,0.0001791139,0.0001742109,0.00009532343,0.00008605385,0.000009098506,0.00007740479,0.0003003184,0.000001456187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003507935,"about_ca_system_score_gemma":0.00009166948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004090002,"about_ca_topic_score_gemma":7.416563e-7,"domain_scores_codex":[0.998718,0.00004509134,0.0004502119,0.0002583326,0.0001828625,0.0003454685],"domain_scores_gemma":[0.9991179,0.000006651941,0.0002739506,0.0002599006,0.0001855284,0.0001560699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000068559,0.00004862194,0.0002621527,0.00007293819,0.00005949148,0.000009214278,0.000009065013,0.0005126728,0.9986488,0.00004268558,0.0000939974,0.0001718191],"study_design_scores_gemma":[0.0004854941,0.0002930661,0.00008353564,0.00005291483,0.00001133843,0.0003966215,0.00002404688,0.00006957031,0.991524,0.0006683653,0.006140561,0.0002505019],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953448,0.002685429,0.001261091,0.00005700587,0.00009456273,0.000185434,0.00001327412,0.00001387705,0.0003445121],"genre_scores_gemma":[0.9936798,0.00008016324,0.005265455,0.00006700202,0.0004594571,0.00001160315,0.00001625186,0.00002172936,0.0003985355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007124799,"threshold_uncertainty_score":0.7304053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01680612729912251,"score_gpt":0.2172049100035432,"score_spread":0.2003987827044207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}