{"id":"W2064456917","doi":"10.1016/j.jmb.2007.06.001","title":"A Mechanistic View of Enzyme Inhibition and Peptide Hydrolysis in the Active Site of the SARS-CoV 3C-like Peptidase","year":2007,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; University of Alberta","funders":"National Cancer Institute; Canadian Institutes of Health Research; U.S. Department of Energy; Killam Trusts; Natural Sciences and Engineering Research Council of Canada; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale","keywords":"Tetrahedral carbonyl addition compound; Active site; Stereochemistry; Chemistry; Enzyme; Peptide; Nucleophile; Cleave; Hydrolase; Cleavage (geology); Hydrolysis; Serine; Biochemistry; Catalysis; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001175483,0.00158601,0.001301233,0.0004390663,0.0009715229,0.002131822,0.003279604,0.003190377,0.005559141],"category_scores_gemma":[0.0007694407,0.00100548,0.001287264,0.0001769276,0.00203552,0.00545614,0.001155991,0.00364825,0.001442161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001715449,"about_ca_system_score_gemma":0.001095791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006423875,"about_ca_topic_score_gemma":0.0003756303,"domain_scores_codex":[0.9994484,0.00008030768,0.00004370348,0.000128105,0.0001287357,0.0001706833],"domain_scores_gemma":[0.9996212,0.0001381867,0.00009020752,0.00004130742,0.00005032357,0.00005887356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003089737,0.001087279,0.001701822,0.001860518,0.0002540098,0.006650821,0.0005658292,0.01902494,0.6291383,0.3088543,0.003283958,0.02448847],"study_design_scores_gemma":[0.0009295329,0.003664258,0.003824545,0.0001534792,0.0002941043,0.0073729,0.0008185012,0.1217977,0.6905977,0.1460641,0.02424818,0.0002350542],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6800522,0.02739046,0.195485,0.03399947,0.003652212,0.0008098573,0.0009784567,0.001154297,0.05647807],"genre_scores_gemma":[0.9763333,0.005214651,0.01033185,0.001164487,0.0003280754,0.0001950408,0.0002392038,0.00003428405,0.00615906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005559141,"threshold_uncertainty_score":0.01859719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02170087359578637,"score_gpt":0.3372845713134548,"score_spread":0.3155836977176684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}