{"id":"W2064457055","doi":"10.1016/j.neuropharm.2010.08.007","title":"3D structure and allosteric modulation of the transmembrane domain of pentameric ligand-gated ion channels","year":2010,"lang":"en","type":"review","venue":"Neuropharmacology","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Allosteric regulation; Transmembrane domain; Ion channel; Ligand-gated ion channel; Biophysics; Chemistry; Light-gated ion channel; Transmembrane protein; Glycine receptor; GABAA receptor; Cys-loop receptors; Receptor; Biochemistry; Acetylcholine receptor; Nicotinic acetylcholine receptor; Biology; Amino acid; Glycine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002719772,0.0007167212,0.001042653,0.0005671245,0.000166859,0.0006351474,0.001063695,0.000754208,0.001187168],"category_scores_gemma":[0.0002273438,0.0002820825,0.0002487297,0.0009932801,0.0005194717,0.0008642784,0.00051367,0.0008659509,0.001106938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006522052,"about_ca_system_score_gemma":0.0004747011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007744856,"about_ca_topic_score_gemma":0.0009024011,"domain_scores_codex":[0.9999292,0.000008210484,0.000008226638,0.00001799581,0.00002578543,0.00001064345],"domain_scores_gemma":[0.9999381,0.00001638127,0.00001659903,0.000003858619,0.00001682897,0.00000821308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002350142,0.00006844327,0.000243561,0.01114077,0.00007236643,0.0004657554,0.0001019127,0.0017809,0.05986537,0.01390038,0.0142145,0.897911],"study_design_scores_gemma":[0.00005547853,0.0001812876,0.001849454,0.001148422,0.0001581679,0.002325619,0.00008305407,0.001036244,0.01650326,0.009057088,0.9675454,0.00005651144],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00153334,0.9957864,0.0008795257,0.0002215227,0.0001923032,0.000006132102,0.00002821695,0.00001926708,0.001333329],"genre_scores_gemma":[0.004451024,0.9937714,0.0005907447,0.0001476814,0.0001318973,0.000007241539,0.00005437249,0.000002416581,0.0008433138],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001187168,"threshold_uncertainty_score":0.004732132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0135567268541292,"score_gpt":0.2995777815928469,"score_spread":0.2860210547387177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}