{"id":"W2064469954","doi":"10.1016/j.ddmec.2008.02.009","title":"Severe malaria and host response: time for a paradigm shift in therapeutic strategies to improve clinical outcome","year":2007,"lang":"en","type":"article","venue":"Drug Discovery Today Disease Mechanisms","topic":"Malaria Research and Control","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Toronto General Hospital; Centre for Global Health Research","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Ontario Genomics Institute; Genome Canada","keywords":"Paradigm shift; Malaria; Outcome (game theory); Medicine; Host (biology); Host response; Intensive care medicine; Psychology; Immunology; Biology; Immune system; Economics; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009718489,0.0006054158,0.002772065,0.0005636187,0.00100776,0.005482588,0.001193854,0.005406451,0.009490127],"category_scores_gemma":[0.005736893,0.0002612207,0.0006351795,0.0005911852,0.006546807,0.009212756,0.00243109,0.01045073,0.001214896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002341047,"about_ca_system_score_gemma":0.003899508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006558814,"about_ca_topic_score_gemma":0.001319239,"domain_scores_codex":[0.9981968,0.000773037,0.0001276635,0.0001739782,0.0003836443,0.0003448805],"domain_scores_gemma":[0.9930595,0.003881444,0.0005507747,0.0004248562,0.0007810752,0.001302326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004487655,0.0008783666,0.006356001,0.002812936,0.0002336667,0.001007936,0.0009061997,0.002052115,0.02197363,0.3419779,0.1498811,0.4674325],"study_design_scores_gemma":[0.0008478115,0.002809885,0.0154325,0.001497601,0.0001817628,0.002541698,0.003952344,0.001917294,0.004083481,0.349419,0.6171002,0.000216377],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.02085498,0.3102538,0.01121762,0.6331175,0.008495575,0.00005675661,0.0002263834,0.0002197404,0.01555766],"genre_scores_gemma":[0.3976741,0.3146144,0.01951875,0.2157075,0.04406649,0.000262814,0.0003446983,0.0001960236,0.007615312],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.009718489,"threshold_uncertainty_score":0.05139691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01964090455670625,"score_gpt":0.3360002072141534,"score_spread":0.3163593026574471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}