{"id":"W2064475159","doi":"10.1016/j.ccell.2014.11.014","title":"mTORC1 Activation Blocks BrafV600E-Induced Growth Arrest but Is Insufficient for Melanoma Formation","year":2015,"lang":"en","type":"article","venue":"Cancer Cell","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":151,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute of General Medical Sciences; National Cancer Institute; University of Vermont; Yale University","keywords":"mTORC1; Melanoma; Cancer research; CDKN2A; PI3K/AKT/mTOR pathway; Microphthalmia-associated transcription factor; Protein kinase B; mTORC2; Downregulation and upregulation; Biology; Medicine; Signal transduction; Cell biology; Cancer; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003039753,0.0006787488,0.0006038645,0.000754185,0.0004720245,0.0004969813,0.0007088144,0.0007539619,0.003706189],"category_scores_gemma":[0.0003123599,0.0004177839,0.0004483462,0.0004143487,0.0006052023,0.0004446918,0.0003503321,0.001929767,0.001043316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008800488,"about_ca_system_score_gemma":0.001140353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003954209,"about_ca_topic_score_gemma":0.006627754,"domain_scores_codex":[0.9993603,0.0001032445,0.00007617797,0.00008628129,0.000154661,0.0002194266],"domain_scores_gemma":[0.9996786,0.0000700212,0.00005018115,0.00003967828,0.00002335497,0.0001381822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006057504,0.0003207186,0.0001637399,0.00006365116,0.00002041135,0.000128086,0.00002571747,0.0002816948,0.9949282,0.0007562679,0.000646687,0.002059029],"study_design_scores_gemma":[0.00006658542,0.0005712878,0.001466688,0.000006391167,0.00002046551,0.0002127237,0.00003515484,0.001286217,0.9926804,0.0001193375,0.003526274,0.000008432222],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984404,0.002042916,0.001620228,0.0007460119,0.0002558697,0.00009310216,0.001688913,0.0005466134,0.008602343],"genre_scores_gemma":[0.99233,0.0005890924,0.00144309,0.0001058836,0.00002469668,0.00008362713,0.001070417,0.00008782002,0.004265386],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003954209,"threshold_uncertainty_score":0.01239842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03470579396947975,"score_gpt":0.2803570395956434,"score_spread":0.2456512456261636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}