{"id":"W2064508165","doi":"10.1016/j.atherosclerosis.2015.03.014","title":"The lipid-lowering effects of lomitapide are unaffected by adjunctive apheresis in patients with homozygous familial hypercholesterolaemia – A post-hoc analysis of a Phase 3, single-arm, open-label trial","year":2015,"lang":"en","type":"article","venue":"Atherosclerosis","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université du Québec à Chicoutimi; Western University","funders":"National Center for Research Resources; Aegerion Pharmaceuticals","keywords":"Open label; Post-hoc analysis; Medicine; Familial hypercholesterolemia; Post hoc; Apheresis; Internal medicine; Clinical trial; Cholesterol; Platelet","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000914788,0.0003381827,0.001459519,0.0002344303,0.0000959117,0.00005079218,0.0003649486,0.0001848127,0.000005009],"category_scores_gemma":[0.000621395,0.0002217497,0.0003093652,0.001589555,0.0001761865,0.0001852896,0.0001601438,0.0002645636,0.000001741518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002920518,"about_ca_system_score_gemma":0.0002323844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002146033,"about_ca_topic_score_gemma":0.0008049698,"domain_scores_codex":[0.9970105,0.0004405515,0.000672154,0.000517059,0.0009074069,0.0004523079],"domain_scores_gemma":[0.9973655,0.0003347819,0.0004874041,0.0009727416,0.0005634952,0.0002760582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5192238,0.05598093,0.1362747,0.001035002,0.01954273,0.00003966912,0.00581268,0.00008255754,0.08391149,0.00001314835,0.0009898546,0.1770935],"study_design_scores_gemma":[0.5897796,0.06381249,0.3212103,0.001478745,0.00696286,0.000002238593,0.001010797,0.0001964409,0.01471259,0.000007712917,0.0001859845,0.0006402437],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956551,0.0005085124,0.00008851288,0.00006987,0.000184976,0.003280725,0.0001301515,0.00002985162,0.00005235928],"genre_scores_gemma":[0.9991074,0.00006046648,0.0002130841,0.0001485204,0.00006464891,0.0002351535,0.00008004241,0.00006219954,0.00002848013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1849356,"threshold_uncertainty_score":0.9042688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02724166884549335,"score_gpt":0.2739147305378492,"score_spread":0.2466730616923559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}