{"id":"W2064521288","doi":"10.1016/j.reprotox.2010.11.013","title":"Combined retrospective analysis of 498 rat multi-generation reproductive toxicity studies: On the impact of parameters related to F1 mating and F2 offspring","year":2010,"lang":"en","type":"article","venue":"Reproductive Toxicology","topic":"Effects and risks of endocrine disrupting chemicals","field":"Environmental Science","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Canada","funders":"Rijksinstituut voor Volksgezondheid en Milieu; National Academy of Sciences","keywords":"Offspring; Reproductive toxicity; Retrospective cohort study; Toxicity; Reproduction; Mating; First generation; Risk assessment; Medicine; Toxicology; Biology; Environmental health; Internal medicine; Zoology; Pregnancy; Computer science; Ecology; Genetics; Population","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00154952,0.0002166109,0.0006340768,0.0001416826,0.0001518638,0.000009786334,0.000180178,0.00008671754,0.00007455418],"category_scores_gemma":[0.008197652,0.0001395794,0.0001822556,0.0009687298,0.0006625242,0.00009824651,0.0002591391,0.000350059,0.000005577237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00020613,"about_ca_system_score_gemma":0.00001211325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003890037,"about_ca_topic_score_gemma":0.0001238178,"domain_scores_codex":[0.997787,0.0002655108,0.0004953067,0.0009882274,0.0002057307,0.0002582153],"domain_scores_gemma":[0.9979723,0.0005056771,0.000491466,0.0008471423,0.0001210599,0.00006236757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008301945,0.0002685969,0.1086929,0.000005514259,0.0008135193,0.000001504008,0.002905892,0.0148483,0.8717516,0.0002325542,0.00009038922,0.0003061917],"study_design_scores_gemma":[0.0002323373,0.0007703033,0.2989021,0.00000941772,0.0001934998,0.000002915562,0.0004707065,0.003104538,0.6958063,0.0003705824,9.989787e-7,0.0001363084],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981705,0.00001970882,0.00001590115,0.0006704772,0.0002059987,0.0006927912,0.00001228842,0.00002278971,0.0001895569],"genre_scores_gemma":[0.9976035,0.00001102889,0.002177126,0.00003208478,0.00003236872,0.00003712633,0.000004524388,0.00001448291,0.00008778138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1902092,"threshold_uncertainty_score":0.9813948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03070748537722106,"score_gpt":0.3788540131453372,"score_spread":0.3481465277681162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}