{"id":"W2064528811","doi":"10.1159/000218178","title":"Transcriptional Control of Pacemaker Channel Genes &lt;i&gt;HCN2&lt;/i&gt; and &lt;i&gt;HCN4&lt;/i&gt; by Sp1 and Implications in Re-expression of These Genes in Hypertrophied Myocytes","year":2009,"lang":"en","type":"article","venue":"Cellular Physiology and Biochemistry","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute","funders":"","keywords":"Downregulation and upregulation; Biology; Sp1 transcription factor; GATA4; Muscle hypertrophy; Internal medicine; Gene expression; Gene; Myocyte; HCN channel; Promoter; Endocrinology; Medicine; Genetics; Ion channel","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002372176,0.0003353974,0.000876178,0.0001143513,0.0001009403,0.000007084583,0.00008400985,0.000369706,0.0000141902],"category_scores_gemma":[0.00006042082,0.0002811509,0.000136745,0.000175543,0.0007106083,0.00005780437,0.00006173175,0.0001730892,5.139692e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002480314,"about_ca_system_score_gemma":0.00005612223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003053727,"about_ca_topic_score_gemma":0.000004005746,"domain_scores_codex":[0.9983193,0.00009266657,0.000513906,0.0005803154,0.0001534112,0.0003404423],"domain_scores_gemma":[0.9990829,0.0001392352,0.0001820249,0.0003469297,0.0001210735,0.0001278691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007911229,0.000341518,0.0008915729,0.0003412436,0.00008567217,0.00001676067,0.0003696757,0.000006576563,0.9957094,0.0002672052,0.0002715141,0.000907763],"study_design_scores_gemma":[0.003728714,0.0002794923,0.07782558,0.0002436031,0.0001713684,0.00007463776,0.0001178786,0.00008658954,0.9143791,0.0005420812,0.002263794,0.0002871513],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8959616,0.1025514,0.00006792964,0.000613429,0.0000413138,0.0003347748,0.0001737702,0.00001819268,0.0002376091],"genre_scores_gemma":[0.9872445,0.01188276,0.0001160521,0.0001455875,0.0001536382,0.00005422627,0.0001849356,0.00001771754,0.0002005946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09128289,"threshold_uncertainty_score":0.9999641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009353817742606565,"score_gpt":0.2217423714651825,"score_spread":0.212388553722576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}