{"id":"W2064528811","doi":"10.1159/000218178","title":"Transcriptional Control of Pacemaker Channel Genes &lt;i&gt;HCN2&lt;/i&gt; and &lt;i&gt;HCN4&lt;/i&gt; by Sp1 and Implications in Re-expression of These Genes in Hypertrophied Myocytes","year":2009,"lang":"en","type":"article","venue":"Cellular Physiology and Biochemistry","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute","funders":"","keywords":"Downregulation and upregulation; Biology; Sp1 transcription factor; GATA4; Muscle hypertrophy; Internal medicine; Gene expression; Gene; Myocyte; HCN channel; Promoter; Endocrinology; Medicine; Genetics; Ion channel","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001344023,0.0002767913,0.0001684109,0.0001470464,0.0001331042,0.0001636185,0.0001368676,0.0001680602,0.001306431],"category_scores_gemma":[0.00009955642,0.0001152895,0.0003192069,0.0000829169,0.0003316268,0.000132025,0.0001946516,0.0005026552,0.0002573625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002774905,"about_ca_system_score_gemma":0.0002446264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006155534,"about_ca_topic_score_gemma":0.001001755,"domain_scores_codex":[0.9998559,0.00001928729,0.000009422458,0.00005739104,0.00002938088,0.00002852226],"domain_scores_gemma":[0.9999052,0.00001465329,0.00002614794,0.00001051346,0.00001771127,0.00002567763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004864478,0.000007516084,0.0002039609,0.00001578992,0.000001644438,0.00002590339,0.00001256173,0.00002485146,0.9989024,0.00008949525,0.00002606587,0.00064103],"study_design_scores_gemma":[0.00002352176,0.0001718568,0.02153881,0.00001523815,0.0000190703,0.0002871745,0.00008777132,0.002001875,0.972061,0.0001911809,0.003594295,0.000008244412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860599,0.001704773,0.008754516,0.000180468,0.00007992646,0.00003511347,0.0009098756,0.00009734905,0.002178092],"genre_scores_gemma":[0.9880775,0.0006868781,0.004951554,0.0001406201,0.00002166156,0.00006906896,0.001129507,0.0000574336,0.004865816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001306431,"threshold_uncertainty_score":0.004370511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009353817742606565,"score_gpt":0.2217423714651825,"score_spread":0.212388553722576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}