{"id":"W2064549315","doi":"10.1159/000340056","title":"Randomized, Double-Blind, Parallel-Group, 48-Week Study for Efficacy and Safety of a Higher-Dose Rivastigmine Patch (15 vs. 10 cm<sup>2</sup>) in Alzheimers Disease","year":2012,"lang":"en","type":"article","venue":"Dementia and Geriatric Cognitive Disorders","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"Cilag; Novartis Pharma; Allergan; H. Lundbeck A/S; Merz Pharmaceuticals; Novo Nordisk; Eisai; Sanofi; GlaxoSmithKline; Pfizer; Novartis Pharmaceuticals Corporation; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Rivastigmine; Tolerability; Medicine; Dementia; Activities of daily living; Randomized controlled trial; Alzheimer's disease; Cognitive decline; Internal medicine; Adverse effect; Donepezil; Disease; Physical therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001631634,0.0004949756,0.001116282,0.0005643673,0.0002074467,0.00005500881,0.0001163105,0.0001096486,0.0007926244],"category_scores_gemma":[0.0003527596,0.0004280951,0.0002778092,0.0006512696,0.0004295271,0.0003135649,0.0002057999,0.0002397032,0.00001628613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002577925,"about_ca_system_score_gemma":0.000107248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002238196,"about_ca_topic_score_gemma":0.0000480577,"domain_scores_codex":[0.9964446,0.000425753,0.0008967788,0.0007153922,0.0006101045,0.0009073631],"domain_scores_gemma":[0.9976575,0.0009557385,0.0002506752,0.0002243265,0.000300438,0.0006113173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5516829,0.006497062,0.4190909,0.0003161778,0.002167016,0.0000141123,0.001453059,0.000002591076,0.000009989355,0.00008072255,0.000297737,0.01838778],"study_design_scores_gemma":[0.5582029,0.001366397,0.4308357,0.0001035308,0.004600433,0.000002262775,0.003134897,0.0002219411,0.00001195076,0.0001142165,0.001033275,0.0003724972],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9767278,0.009710614,0.001012487,0.0005147894,0.0001299545,0.01112217,0.0001025035,0.00003587849,0.0006437422],"genre_scores_gemma":[0.9944382,0.001832298,0.0001364421,0.0001514816,0.0001239387,0.002347593,0.0004556892,0.00005508979,0.0004593061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01801529,"threshold_uncertainty_score":0.9998171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02669365877260926,"score_gpt":0.3220197765321212,"score_spread":0.2953261177595119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}