{"id":"W2064554777","doi":"10.1074/jbc.m007640200","title":"Endoplasmic Reticulum (ER)-associated Degradation of T Cell Receptor Subunits","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Endoplasmic reticulum; Cell biology; Endoplasmic-reticulum-associated protein degradation; Chemistry; Receptor; STIM1; Degradation (telecommunications); Biochemistry; Biology; Unfolded protein response; Computer science","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001293155,0.000334213,0.0001567871,0.0002079753,0.0002196432,0.000427498,0.0001502735,0.0002915048,0.0009965033],"category_scores_gemma":[0.0001349311,0.00009498597,0.000308941,0.0002064347,0.0001211586,0.0002075888,0.0002576306,0.0003882273,0.001076426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004281085,"about_ca_system_score_gemma":0.0002313467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004653401,"about_ca_topic_score_gemma":0.0003390743,"domain_scores_codex":[0.9998621,0.00001567755,0.0000125549,0.00003465357,0.00004048863,0.0000345719],"domain_scores_gemma":[0.9998639,0.000008955495,0.00004200065,0.00002022424,0.0000382277,0.00002669319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006919412,0.00001323069,0.0005548749,0.00003922505,0.000006665795,0.0001233048,0.000009030982,0.00005695739,0.9962303,0.00014051,0.00009753265,0.002659084],"study_design_scores_gemma":[0.000007993878,0.0001142682,0.01288475,0.00001031927,0.00001516105,0.001249297,0.0000336261,0.001190152,0.97585,0.00007195479,0.008566478,0.00000600297],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9771689,0.008425436,0.01057321,0.000193508,0.00006314071,0.00003648987,0.001000208,0.0001849716,0.002354237],"genre_scores_gemma":[0.9813966,0.004240425,0.004469162,0.0001006091,0.00002257577,0.0000285029,0.001771942,0.00003361052,0.007936548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009965033,"threshold_uncertainty_score":0.003333628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01375831473188512,"score_gpt":0.2322662207522471,"score_spread":0.218507906020362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}