{"id":"W2064572849","doi":"10.1016/s0040-4039(01)01469-1","title":"Construction of cis - and trans -octahydroisoquinoline-7-ones via a tandem ring-opening and -closing strategy","year":2001,"lang":"en","type":"article","venue":"Tetrahedron Letters","topic":"Synthesis and Biological Activity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of New Brunswick","funders":"","keywords":"Chemistry; Tandem; Stereoselectivity; Closing (real estate); Ring (chemistry); Stereochemistry; Transformation (genetics); Combinatorial chemistry; Catalysis; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000116563,0.000131685,0.0001781354,0.00003350028,0.00006682699,0.00001886267,0.00005674951,0.0001112334,0.00001722139],"category_scores_gemma":[0.00001898738,0.000110181,0.00004496042,0.00005423814,0.0002294575,0.00000858823,0.00002965545,0.00007180953,3.293473e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000646445,"about_ca_system_score_gemma":0.000006402798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006724981,"about_ca_topic_score_gemma":0.00002012096,"domain_scores_codex":[0.9992644,0.00004615327,0.0001695723,0.0002773908,0.00006810898,0.0001743562],"domain_scores_gemma":[0.9997356,0.00002443812,0.00007402931,0.00009742417,0.00001492019,0.00005360054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005856253,0.00002200763,0.03940203,0.00001272195,0.00002773696,0.000003581977,0.00002199297,0.00001060162,0.9237572,0.0000187336,0.00001311854,0.03665169],"study_design_scores_gemma":[0.001031627,0.0006912611,0.1365813,0.00005627364,0.00006507033,0.0004409674,0.0002104795,0.0004658361,0.8580418,0.0001800761,0.001772519,0.0004627439],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934189,0.0004271333,0.00527374,0.0004706036,0.00003813422,0.00008999572,0.000005136089,0.0000122411,0.0002640927],"genre_scores_gemma":[0.9985074,0.000364752,0.0008054331,0.0002007991,0.0000911149,0.00000333297,0.000008893649,0.000008673881,0.000009557793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09717932,"threshold_uncertainty_score":0.449305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01307231227648556,"score_gpt":0.2303606033470111,"score_spread":0.2172882910705255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}