{"id":"W2064613874","doi":"10.1139/v01-200","title":"2001 Lemieux Award Lecture Organic chemistry and hemoglobin: Benefits from controlled alteration","year":2002,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Hemoglobin structure and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Hemoglobin; Cooperativity; Nitric oxide; Oxygen; Methemoglobin; Blood substitute; Red blood cell; Heme; Biophysics; Biochemistry; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001097822,0.0002172607,0.0003106956,0.00001956063,0.0001183326,0.00007822759,0.0001851005,0.0003519039,0.002292939],"category_scores_gemma":[0.0002340264,0.0002049654,0.0001245554,0.00008018547,0.00007685331,0.00001199684,0.00001664752,0.0002610386,0.000004647457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007673186,"about_ca_system_score_gemma":0.0003403754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001253541,"about_ca_topic_score_gemma":0.0004367413,"domain_scores_codex":[0.9989148,0.0000197993,0.0003693659,0.0002479501,0.0001352141,0.0003128903],"domain_scores_gemma":[0.9987071,0.00001570759,0.0002320262,0.0002361919,0.0002143699,0.0005945625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007789682,0.00001036806,0.001406995,0.00002426273,0.0001293001,0.0000350681,0.00006643011,0.00006805674,0.9713926,4.22937e-7,0.02304048,0.003748167],"study_design_scores_gemma":[0.004477307,0.00009258132,0.0006166846,0.00007031721,0.000110494,0.0009491529,0.0000992203,0.00018653,0.9019675,0.0001023844,0.09091952,0.0004083383],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871246,0.008522286,0.0003985201,0.0007872259,0.000248623,0.00007766155,0.00006837444,0.000004907504,0.002767805],"genre_scores_gemma":[0.9961677,0.0003600617,0.0001946454,0.0004502432,0.001408264,0.00000245921,0.000100656,0.0000250873,0.001290857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06942509,"threshold_uncertainty_score":0.9986191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006195562421446554,"score_gpt":0.1812447079553604,"score_spread":0.1750491455339139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}