{"id":"W2064654911","doi":"10.1515/bc.2008.109","title":"Regulation of cathepsin K activity by hydrogen peroxide","year":2008,"lang":"en","type":"article","venue":"Biological Chemistry","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Chemistry; Hydrogen peroxide; Cathepsin; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002891766,0.0002407939,0.000284253,0.0001442285,0.0001352292,0.0005496023,0.0001801063,0.0002824961,0.0006973316],"category_scores_gemma":[0.0002947252,0.0001344612,0.0001929128,0.0001269401,0.0003728497,0.0002710897,0.0002179387,0.0003838284,0.000196487],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003211667,"about_ca_system_score_gemma":0.0001542261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004608892,"about_ca_topic_score_gemma":0.0003751878,"domain_scores_codex":[0.9997671,0.00005734229,0.00002208104,0.00004247514,0.00004071664,0.00007026274],"domain_scores_gemma":[0.9998125,0.00004528306,0.00004947099,0.00003222364,0.00002856441,0.00003190644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003391392,0.0000363885,0.0002988042,0.00002225197,0.000005263275,0.00003938237,0.00001968004,0.00003229194,0.9981399,0.00007157103,0.00003831444,0.000957004],"study_design_scores_gemma":[0.0000362486,0.000374486,0.007053771,0.000003010233,0.00001043933,0.0001275027,0.00003973123,0.0006723019,0.9906676,0.000103796,0.0009042933,0.000006875998],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957089,0.00228369,0.001130757,0.0001089038,0.00002331847,0.00001598733,0.0001017894,0.0000573651,0.0005692376],"genre_scores_gemma":[0.9981588,0.0006396335,0.000485317,0.00002318667,0.000007236224,0.00001389031,0.00008347048,0.000005593352,0.0005829399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006973316,"threshold_uncertainty_score":0.002332866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01643172988560125,"score_gpt":0.2191422821787821,"score_spread":0.2027105522931809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}