{"id":"W2064679735","doi":"10.4155/ppa.14.39","title":"Inhibitors of voltage-gated Sodium Channel Na <sub>v</sub> 1.7: Patent Applications Since 2010","year":2014,"lang":"en","type":"review","venue":"Pharmaceutical Patent Analyst","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"","keywords":"Sodium channel; Chemistry; Sodium; Nanotechnology; Materials science; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000462516,0.0005608789,0.001118897,0.0002721288,0.0001402639,0.00003342157,0.0003376206,0.0006173852,0.00003350542],"category_scores_gemma":[0.00006219094,0.0004773468,0.0009258112,0.0005290066,0.0002104716,0.000007357789,0.0001999375,0.0004039198,0.0001827622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006674723,"about_ca_system_score_gemma":0.0001357206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007985177,"about_ca_topic_score_gemma":0.0000032343,"domain_scores_codex":[0.9970282,0.0002341846,0.001097376,0.0007964501,0.0003921575,0.0004516637],"domain_scores_gemma":[0.9980978,0.00004238893,0.0006266346,0.0005582419,0.0003506582,0.0003242847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001513087,0.0007941754,0.00003540102,0.01111385,0.001478967,0.000006497918,0.0000202162,0.0003110356,0.05483446,0.0002086322,0.007337107,0.9237084],"study_design_scores_gemma":[0.0005047941,0.00009849109,0.000004148549,0.0006037889,0.001252457,0.00001324018,0.000008978575,0.003011667,0.03725037,0.0000158716,0.9566811,0.0005551395],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002568542,0.963002,0.03305689,0.0001080146,0.001473426,0.001633053,0.0001814154,0.0000709405,0.0002174189],"genre_scores_gemma":[0.03806979,0.9560991,0.00002311881,0.0001297022,0.001432506,0.0002539577,0.003562832,0.00009186568,0.0003371551],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9493439,"threshold_uncertainty_score":0.9997678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09180525462218428,"score_gpt":0.3306597990516639,"score_spread":0.2388545444294796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}