{"id":"W2064693858","doi":"10.1046/j.1365-3083.2001.00919.x","title":"<i>In vitro</i> Evaluation of an Enhanced Human Serum Amyloid A (<i>SAA2</i>) Promoter‐Regulated Soluble TNF Receptor Fusion Protein for Anti‐Inflammatory Gene Therapy","year":2001,"lang":"en","type":"article","venue":"Scandinavian Journal of Immunology","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Tumor necrosis factor alpha; Cytokine; Reporter gene; Chemistry; Molecular biology; Fusion protein; Transfection; Receptor antagonist; Serum amyloid A; Receptor; Biology; Gene expression; Inflammation; Immunology; Recombinant DNA; Antagonist; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00107675,0.0002940381,0.0005462611,0.0002552483,0.0001243764,0.00001994225,0.0003781146,0.0003321695,0.000102998],"category_scores_gemma":[0.00008071423,0.0002608704,0.0002426724,0.0001819876,0.0001598903,0.00004638754,0.00005688276,0.0001596856,0.000002345353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001472129,"about_ca_system_score_gemma":0.0002223333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000200676,"about_ca_topic_score_gemma":0.00002873741,"domain_scores_codex":[0.9976108,0.0004446063,0.0008514662,0.000361192,0.0002946364,0.0004373158],"domain_scores_gemma":[0.997925,0.00001655443,0.0009350679,0.000434283,0.0006010376,0.00008804499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00192625,0.0005366167,0.002813172,0.0000151896,0.0002817184,0.000008468313,0.0001783429,0.00004125953,0.9768761,0.000005451352,0.00006921503,0.01724822],"study_design_scores_gemma":[0.008534811,0.002982383,0.01549991,0.0001019764,0.00007081687,0.00009720585,0.0001266978,0.00002042845,0.9715283,0.0001964639,0.0006043608,0.0002366777],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948252,0.003034812,0.0001490721,0.000319466,0.0003568234,0.00125571,0.0000217138,0.000008769547,0.00002841773],"genre_scores_gemma":[0.9972364,0.0008146414,0.001209456,0.00007232095,0.0001817447,0.0001494277,0.0001081674,0.00005009101,0.0001777865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01701154,"threshold_uncertainty_score":0.9999843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01533018598064039,"score_gpt":0.2857051826405318,"score_spread":0.2703749966598914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}