{"id":"W2064693858","doi":"10.1046/j.1365-3083.2001.00919.x","title":"<i>In vitro</i> Evaluation of an Enhanced Human Serum Amyloid A (<i>SAA2</i>) Promoter‐Regulated Soluble TNF Receptor Fusion Protein for Anti‐Inflammatory Gene Therapy","year":2001,"lang":"en","type":"article","venue":"Scandinavian Journal of Immunology","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Tumor necrosis factor alpha; Cytokine; Reporter gene; Chemistry; Molecular biology; Fusion protein; Transfection; Receptor antagonist; Serum amyloid A; Receptor; Biology; Gene expression; Inflammation; Immunology; Recombinant DNA; Antagonist; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004884774,0.0005423645,0.0003912691,0.0001661991,0.0001587358,0.0004497324,0.0002371703,0.0004270536,0.001020735],"category_scores_gemma":[0.0001638441,0.0001603399,0.0004747909,0.000202932,0.000232747,0.0001785453,0.0001240696,0.0005507838,0.0006775383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004198636,"about_ca_system_score_gemma":0.0002004992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005635521,"about_ca_topic_score_gemma":0.0004689276,"domain_scores_codex":[0.9996302,0.0001410613,0.00003066621,0.0000467471,0.00009498595,0.00005631339],"domain_scores_gemma":[0.999856,0.00003480744,0.00003766475,0.00001541009,0.00003112534,0.00002498407],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001195145,0.00005556022,0.00003334651,0.00003075419,0.000004186889,0.00002276374,0.000009509865,0.0001689572,0.9991003,0.00004756003,0.00004290647,0.000364727],"study_design_scores_gemma":[0.00001539365,0.0006063073,0.0001624064,0.000002400502,0.00001054339,0.0000857727,0.000006174981,0.0006311989,0.9972401,0.000008364084,0.001228933,0.00000243195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.977558,0.003623058,0.01401061,0.000224145,0.0001412942,0.0001825967,0.000835047,0.0001723266,0.003253026],"genre_scores_gemma":[0.9805665,0.002055345,0.01204821,0.00009432298,0.00003686407,0.0001760423,0.001639261,0.00006887477,0.0033147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001020735,"threshold_uncertainty_score":0.00341469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01533018598064039,"score_gpt":0.2857051826405318,"score_spread":0.2703749966598914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}