{"id":"W2064732371","doi":"10.1021/bi002331u","title":"Requirements for Osmosensing and Osmotic Activation of Transporter ProP from<i>Escherichia coli</i>","year":2001,"lang":"en","type":"article","venue":"Biochemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Osmolyte; Chemistry; Osmotic shock; Osmotic pressure; Proline; Symporter; Biochemistry; Biophysics; Osmotic concentration; PEG ratio; Hofmeister series; Transporter; Escherichia coli; Membrane potential; Biology; Ion; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005897303,0.0001051576,0.0001908734,0.00001564582,0.00003296147,0.000004616047,0.00003030297,0.00009913005,0.00002471005],"category_scores_gemma":[0.00001097814,0.00009280264,0.00005634674,0.00006819885,0.00004741562,0.00003261291,0.000002775188,0.00005471275,4.046765e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002111141,"about_ca_system_score_gemma":0.00004889014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001183856,"about_ca_topic_score_gemma":0.000001462814,"domain_scores_codex":[0.9993261,0.000002773443,0.0002023037,0.000198697,0.0001350727,0.0001351059],"domain_scores_gemma":[0.9996355,0.00001283774,0.00007300659,0.0001454997,0.00006511207,0.00006804268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000405963,0.00008900593,0.005006847,0.0003350833,0.0000435227,0.000007230363,0.0000918378,2.151273e-7,0.9928424,0.000007745936,0.00007666112,0.001093483],"study_design_scores_gemma":[0.001474343,0.00005572428,0.01043209,0.0003823439,0.0001136185,0.000002525729,0.0001242587,0.00005846413,0.9864664,0.0001534503,0.0006389177,0.00009785524],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951634,0.00009878554,0.003394839,0.0002692125,0.00004206489,0.000286725,0.00001890719,0.0000251425,0.0007009252],"genre_scores_gemma":[0.9938997,0.00002783965,0.004701738,0.0001326374,0.00009619476,0.000009470238,0.0001515667,0.00001700714,0.0009638694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006376001,"threshold_uncertainty_score":0.3784382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02080490735983694,"score_gpt":0.2555487157023784,"score_spread":0.2347438083425415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}