{"id":"W2064746504","doi":"10.1016/j.devcel.2010.12.008","title":"Synaptojanin 1-Mediated PI(4,5)P2 Hydrolysis Is Modulated by Membrane Curvature and Facilitates Membrane Fission","year":2011,"lang":"en","type":"article","venue":"Developmental Cell","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":174,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; McKnight Foundation; Korea University; Harvard University; National Institutes of Health; Yale University; Hospital for Sick Children; Ariad Pharmaceuticals","keywords":"Dynamin; Membrane curvature; Endocytosis; Biology; Cell biology; Pi; Internalization; Phosphatidylinositol; Membrane; Phosphatase; Pleckstrin homology domain; Biophysics; Vesicle; Biochemistry; Signal transduction; Cell; Phosphorylation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002230401,0.0003757134,0.0002957887,0.0002805443,0.0003709147,0.0007597013,0.0002916847,0.0005183764,0.001246808],"category_scores_gemma":[0.0003440123,0.0003461198,0.0003347276,0.0002038526,0.0004527099,0.0009036961,0.0009234335,0.0009237011,0.0006138372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007196595,"about_ca_system_score_gemma":0.0002340684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004831105,"about_ca_topic_score_gemma":0.0008146523,"domain_scores_codex":[0.9998353,0.00002053111,0.00001392213,0.00004012534,0.00004231396,0.00004783765],"domain_scores_gemma":[0.9998254,0.00003446632,0.00004628719,0.00001994375,0.00001697819,0.00005706881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004937286,0.00001302208,0.0003716676,0.00002297896,0.000005127007,0.0001561594,0.00002009555,0.0000874504,0.9973673,0.0006417909,0.00004832216,0.0007724381],"study_design_scores_gemma":[0.00005568143,0.00008897962,0.01784154,0.000006810326,0.00001118702,0.0006344557,0.00008657566,0.004056157,0.9756716,0.0005407904,0.0009900485,0.00001621809],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954433,0.0007061856,0.002560775,0.0002331671,0.00002675775,0.000009287663,0.0001183219,0.0000580546,0.0008441841],"genre_scores_gemma":[0.9979684,0.0002462732,0.0005926052,0.00002465804,0.000005297276,0.000007437734,0.0001998793,0.00001702386,0.0009383769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001246808,"threshold_uncertainty_score":0.005221546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00788474624861134,"score_gpt":0.1771753612689914,"score_spread":0.16929061502038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}