{"id":"W2064806768","doi":"10.1016/j.chembiol.2008.02.016","title":"PAP Inhibitor with In Vivo Efficacy Identified by Candida albicans Genetic Profiling of Natural Products","year":2008,"lang":"en","type":"article","venue":"Chemistry & Biology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"Genome Canada","keywords":"Candida albicans; Biology; Natural product; Drug discovery; Antimicrobial; Computational biology; Fungal pathogen; Profiling (computer programming); Human pathogen; Drug; Corpus albicans; Fermentation; In vivo; Antifungal drug; Microbiology; Pathogen; Biotechnology; Genetics; Bacteria; Bioinformatics; Biochemistry; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002178387,0.0005460352,0.000320524,0.0003473816,0.0001534162,0.000335236,0.0003010288,0.0002449027,0.001432925],"category_scores_gemma":[0.0001707918,0.0001494303,0.0002595356,0.0002253132,0.0002241722,0.0001801589,0.00011921,0.000683378,0.0003250758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002472406,"about_ca_system_score_gemma":0.0003485086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005174853,"about_ca_topic_score_gemma":0.0007112046,"domain_scores_codex":[0.9998511,0.00002791811,0.00001286866,0.00002331165,0.00003824471,0.00004654091],"domain_scores_gemma":[0.9998442,0.000029767,0.0000360224,0.00002070679,0.00002200416,0.00004730795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005446694,0.0002070252,0.0001977591,0.00002196259,0.00001025275,0.00004733761,0.000003468418,0.0001236239,0.9961487,0.00006024099,0.00008109032,0.002553944],"study_design_scores_gemma":[0.00003312241,0.0009699031,0.001110461,0.000001658569,0.00002568417,0.0001392782,0.000004850839,0.0002500789,0.9969488,0.00001254146,0.0005013365,0.000002310288],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990606,0.002027313,0.003800962,0.0001288912,0.00004106548,0.00008817204,0.0009440837,0.0001732037,0.002190309],"genre_scores_gemma":[0.9941245,0.0008522245,0.002170912,0.00004711382,0.00001600584,0.00004639228,0.0008044866,0.00002134078,0.001917075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001432925,"threshold_uncertainty_score":0.004793584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00872602673988873,"score_gpt":0.2258126503576809,"score_spread":0.2170866236177922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}