{"id":"W2064806768","doi":"10.1016/j.chembiol.2008.02.016","title":"PAP Inhibitor with In Vivo Efficacy Identified by Candida albicans Genetic Profiling of Natural Products","year":2008,"lang":"en","type":"article","venue":"Chemistry & Biology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"Genome Canada","keywords":"Candida albicans; Biology; Natural product; Drug discovery; Antimicrobial; Computational biology; Fungal pathogen; Profiling (computer programming); Human pathogen; Drug; Corpus albicans; Fermentation; In vivo; Antifungal drug; Microbiology; Pathogen; Biotechnology; Genetics; Bacteria; Bioinformatics; Biochemistry; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007292945,0.0001777162,0.0003808644,0.00003259517,0.00004447401,0.000003038257,0.0001125638,0.0001596887,0.0001067375],"category_scores_gemma":[0.0002478047,0.0001207443,0.00004152994,0.0002498278,0.000317973,0.00002013084,0.00003775435,0.0002600385,0.000002524405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004785723,"about_ca_system_score_gemma":0.0001558377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001183983,"about_ca_topic_score_gemma":0.000008905299,"domain_scores_codex":[0.9988483,0.00002143817,0.0003042757,0.000457307,0.00008517745,0.0002835242],"domain_scores_gemma":[0.9993688,0.00003277319,0.0001209409,0.0002901181,0.0001280246,0.0000593115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003302513,0.0001327269,0.008491131,0.0002308197,0.0000349727,0.00003324827,0.00007201086,2.313564e-7,0.9884357,6.603458e-7,0.001788565,0.0004496789],"study_design_scores_gemma":[0.001003735,0.00009047982,0.002631808,0.00009072277,0.00003063412,0.000226616,0.00002836122,0.000003448058,0.9936638,0.000001654995,0.002081272,0.0001474031],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963313,0.00223693,7.573221e-7,0.0007579332,0.00009620779,0.000305438,0.00002983819,0.00002459444,0.0002169866],"genre_scores_gemma":[0.9971014,0.0001050609,0.000534889,0.00007844323,0.0002749629,0.000002835862,0.0000821941,0.00001535462,0.001804884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005859324,"threshold_uncertainty_score":0.4923809,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00872602673988873,"score_gpt":0.2258126503576809,"score_spread":0.2170866236177922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}