{"id":"W2064825875","doi":"10.1016/j.micpath.2007.10.007","title":"Caspases-3, -8, and -9 are required for induction of epithelial cell apoptosis by enteropathogenic E. coli but are dispensable for increased paracellular permeability","year":2007,"lang":"en","type":"article","venue":"Microbial Pathogenesis","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Paracellular transport; Apoptosis; Barrier function; Enteropathogenic Escherichia coli; Occludin; Caspase; Cell biology; Tight junction; Intestinal epithelium; Biology; Intestinal permeability; Caco-2; Intestinal mucosa; Programmed cell death; Epithelium; Cell; Immunology; Permeability (electromagnetism); Escherichia coli; Internal medicine; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002382533,0.0002943967,0.0002525354,0.0002948402,0.000207768,0.0005614742,0.00016319,0.0003919951,0.001810765],"category_scores_gemma":[0.0005082309,0.0001946386,0.0002521237,0.0001660522,0.0003337722,0.0004797473,0.0002839277,0.0008740594,0.0006890134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004340467,"about_ca_system_score_gemma":0.0003129006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003339282,"about_ca_topic_score_gemma":0.0005049735,"domain_scores_codex":[0.9995933,0.00008633581,0.00004782726,0.00004347402,0.0001134373,0.0001156436],"domain_scores_gemma":[0.9993345,0.0001410939,0.0001832456,0.00008556943,0.0001287105,0.0001269355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003788046,0.00002830049,0.0004493517,0.00002762166,0.000002884605,0.00008191798,0.00001220989,0.00002735615,0.9977119,0.00009460957,0.00002455096,0.001160484],"study_design_scores_gemma":[0.00003510954,0.0001625838,0.01060287,0.00000920768,0.000009521658,0.0009259533,0.00007030247,0.0004525081,0.9864011,0.0001808058,0.001145286,0.000004617605],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934705,0.001451903,0.003392216,0.0002026216,0.00002266166,0.00001958951,0.0002492644,0.0000619104,0.001129252],"genre_scores_gemma":[0.9956169,0.0004895729,0.001869887,0.00003944391,0.00000572372,0.00001327165,0.000508641,0.00001691731,0.00143968],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001810765,"threshold_uncertainty_score":0.00605762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01610530750313731,"score_gpt":0.2526511280229082,"score_spread":0.2365458205197709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}