{"id":"W2064825875","doi":"10.1016/j.micpath.2007.10.007","title":"Caspases-3, -8, and -9 are required for induction of epithelial cell apoptosis by enteropathogenic E. coli but are dispensable for increased paracellular permeability","year":2007,"lang":"en","type":"article","venue":"Microbial Pathogenesis","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Paracellular transport; Apoptosis; Barrier function; Enteropathogenic Escherichia coli; Occludin; Caspase; Cell biology; Tight junction; Intestinal epithelium; Biology; Intestinal permeability; Caco-2; Intestinal mucosa; Programmed cell death; Epithelium; Cell; Immunology; Permeability (electromagnetism); Escherichia coli; Internal medicine; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008888562,0.0002750401,0.0004119763,0.00005872804,0.00024567,0.00002422021,0.0001792188,0.0002441527,0.000005002275],"category_scores_gemma":[0.0004538842,0.0002788809,0.0002404818,0.0001148603,0.0002278064,0.000009474556,0.0001545428,0.00006372603,9.673008e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005592093,"about_ca_system_score_gemma":0.00007539653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001343714,"about_ca_topic_score_gemma":0.0002144488,"domain_scores_codex":[0.9981455,0.0001261749,0.000428074,0.0006458561,0.0001362616,0.0005181581],"domain_scores_gemma":[0.9987005,0.00009673784,0.0003049384,0.0003797766,0.000373449,0.0001446212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001423917,0.0002952843,0.008792299,0.0003429145,0.00007322632,0.000001249637,0.00003849138,0.000003587138,0.9872366,0.000001637615,0.001334192,0.0004565653],"study_design_scores_gemma":[0.001762058,0.0004966686,0.007379453,0.000026862,0.0001049894,0.000004443296,0.0003518592,0.00002899302,0.9849066,0.000008931341,0.004647334,0.0002817866],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888671,0.001245254,0.004894675,0.00007036823,0.0001456021,0.001362937,0.003392051,0.00001330368,0.00000869885],"genre_scores_gemma":[0.9964513,0.0002365485,0.002065731,0.00007433291,0.0002636339,0.0001940919,0.000374389,0.00005008922,0.0002899475],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007584127,"threshold_uncertainty_score":0.9999663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01610530750313731,"score_gpt":0.2526511280229082,"score_spread":0.2365458205197709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}