{"id":"W2064877487","doi":"10.1006/jsbi.2000.4222","title":"Review: Amyloidogenesis—Unquestioned Answers and Unanswered Questions","year":2000,"lang":"en","type":"review","venue":"Journal of Structural Biology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":128,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University; Kingston General Hospital","funders":"","keywords":"Amyloid (mycology); Amyloid fibril; Proteolysis; In vitro; In vivo; Amyloidosis; Computational biology; Fibril; Chemistry; Protein aggregation; Biophysics; Biochemistry; Biology; Amyloid β; Medicine; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001721397,0.002128091,0.004358056,0.002637508,0.0009008873,0.002754504,0.002806511,0.00358942,0.004425786],"category_scores_gemma":[0.004207802,0.000420099,0.0007481163,0.005063894,0.001839845,0.004865455,0.00148024,0.005499976,0.005267137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001809213,"about_ca_system_score_gemma":0.003181866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001868339,"about_ca_topic_score_gemma":0.003943454,"domain_scores_codex":[0.9994156,0.0001192007,0.0001005618,0.00008647553,0.0002255812,0.00005259251],"domain_scores_gemma":[0.9976348,0.0009286787,0.0002379437,0.0000614429,0.0008220759,0.0003151505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001308493,0.00002995099,0.0001020787,0.009232817,0.00007205379,0.0002370609,0.00005037506,0.000135459,0.0005059777,0.00186204,0.6659943,0.3216469],"study_design_scores_gemma":[0.00003458533,0.00003682604,0.0003617996,0.00340085,0.00009913158,0.0008088461,0.0001293028,0.00005845529,0.00009248437,0.003480907,0.9914749,0.00002199577],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004139359,0.9836462,0.0001037198,0.005604007,0.009870241,0.000008672002,0.00002905232,0.00001651379,0.000680309],"genre_scores_gemma":[0.0003469389,0.9866685,0.0001780281,0.00452224,0.007442513,0.00001222317,0.00004428589,0.000003341929,0.0007820161],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004425786,"threshold_uncertainty_score":0.01480573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04855970002296151,"score_gpt":0.4003452500447516,"score_spread":0.3517855500217901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}