{"id":"W2064877487","doi":"10.1006/jsbi.2000.4222","title":"Review: Amyloidogenesis—Unquestioned Answers and Unanswered Questions","year":2000,"lang":"en","type":"review","venue":"Journal of Structural Biology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":128,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University; Kingston General Hospital","funders":"","keywords":"Amyloid (mycology); Amyloid fibril; Proteolysis; In vitro; In vivo; Amyloidosis; Computational biology; Fibril; Chemistry; Protein aggregation; Biophysics; Biochemistry; Biology; Amyloid β; Medicine; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001879341,0.0003743325,0.002192243,0.0003138392,0.00008772775,0.00001368176,0.0001508194,0.0002969961,0.000342479],"category_scores_gemma":[0.0001367618,0.0002159494,0.0005907647,0.0002361267,0.0002489543,0.00007727285,0.00003389506,0.0005160607,0.00002810192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001438035,"about_ca_system_score_gemma":0.0007535768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002119511,"about_ca_topic_score_gemma":0.000001348008,"domain_scores_codex":[0.9979792,0.0003407594,0.0009237016,0.0002597596,0.0001794544,0.0003170801],"domain_scores_gemma":[0.9982927,0.0001261377,0.0006172211,0.0002397522,0.0002375982,0.000486634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009809226,0.00003026887,0.0001933037,0.009925627,0.006127378,0.0002508382,0.000004020944,3.289175e-8,0.000001385748,0.00004718149,0.001248506,0.9820734],"study_design_scores_gemma":[0.0009428414,0.00102239,0.0006226391,0.03943524,0.01185801,0.009516214,0.000003127839,4.617251e-7,0.000001031498,0.0003706773,0.9359689,0.0002585131],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002036727,0.9984632,9.45074e-7,0.0003016008,0.0001821144,0.0006019609,0.0001329462,0.00001325231,0.0001002875],"genre_scores_gemma":[0.0002414561,0.9985907,0.0003391535,0.0001755668,0.0003474927,0.00001299229,0.000227438,0.00002840863,0.00003679998],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9818149,"threshold_uncertainty_score":0.8806161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04855970002296151,"score_gpt":0.4003452500447516,"score_spread":0.3517855500217901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}