{"id":"W2064881435","doi":"10.1021/jm301103y","title":"New Ruthenium(II)–Letrozole Complexes as Anticancer Therapeutics","year":2012,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Letrozole; Chemistry; Aromatase; Ruthenium; Breast cancer; Cytotoxicity; Cancer cell; Cancer research; Cancer; In vitro; Programmed cell death; MCF-7; Pharmacology; Internal medicine; Biochemistry; Apoptosis; Human breast; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001035363,0.0002731289,0.0002681457,0.0002639677,0.0001130711,0.0002898387,0.000383747,0.0002857167,0.0009489025],"category_scores_gemma":[0.0001140151,0.0001445158,0.0001555301,0.0001360631,0.0001401396,0.0002184827,0.0001712643,0.0002609362,0.0003232164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003124245,"about_ca_system_score_gemma":0.0001126929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002864944,"about_ca_topic_score_gemma":0.0007243565,"domain_scores_codex":[0.9999131,0.00002022776,0.000007716775,0.00001611947,0.00002442771,0.00001836771],"domain_scores_gemma":[0.999962,0.000005079838,0.00001356749,0.000004156434,0.000006431574,0.000008806333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003348217,0.00005289327,0.0001544535,0.0002394668,0.0000380427,0.0001541269,0.00005896638,0.0005734889,0.9871773,0.001249648,0.0003246765,0.009642085],"study_design_scores_gemma":[0.00007419615,0.0005977048,0.0004747274,0.00001216024,0.00005701237,0.0002747632,0.00001510953,0.0009895448,0.9831701,0.0001062927,0.0142133,0.00001517348],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9620739,0.01234292,0.0159631,0.0003754932,0.00007750255,0.0002174747,0.0002915422,0.0004271629,0.008230975],"genre_scores_gemma":[0.986335,0.002309677,0.007045295,0.00008257358,0.00001517884,0.00003484794,0.0002120622,0.00002386725,0.003941464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009489025,"threshold_uncertainty_score":0.003174424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05075768399777041,"score_gpt":0.314303096036568,"score_spread":0.2635454120387976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}