{"id":"W2064881435","doi":"10.1021/jm301103y","title":"New Ruthenium(II)–Letrozole Complexes as Anticancer Therapeutics","year":2012,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Letrozole; Chemistry; Aromatase; Ruthenium; Breast cancer; Cytotoxicity; Cancer cell; Cancer research; Cancer; In vitro; Programmed cell death; MCF-7; Pharmacology; Internal medicine; Biochemistry; Apoptosis; Human breast; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005856679,0.0001894254,0.0005593849,0.00004760009,0.00008809197,0.00001383099,0.0001931202,0.0001002755,0.003161347],"category_scores_gemma":[0.0001782676,0.0001209639,0.0002190958,0.0001090099,0.0001134031,0.0001229489,0.00004716653,0.0004852896,0.00002977671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007401514,"about_ca_system_score_gemma":0.0002925605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001954075,"about_ca_topic_score_gemma":1.955728e-7,"domain_scores_codex":[0.9981907,0.0000317692,0.0005559663,0.00009755249,0.0007837774,0.0003402518],"domain_scores_gemma":[0.9986446,0.00009528299,0.0003438587,0.0002250035,0.0001886795,0.0005026032],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006850998,0.0001873337,0.005601633,0.0001899073,0.0002909621,0.00002722794,0.0007663894,6.600123e-7,0.9743441,0.00006618642,0.00879789,0.009042558],"study_design_scores_gemma":[0.001531389,0.0005612295,0.00416339,0.0005347559,0.000632926,0.003709672,0.0008758363,0.00001204945,0.7230753,0.000238608,0.2644863,0.0001785596],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9539529,0.02006971,0.0002976844,0.004122346,0.000401858,0.0000666466,0.000001801712,0.00001604088,0.02107098],"genre_scores_gemma":[0.987695,0.0004564247,0.002171451,0.001376515,0.00368828,7.561882e-7,0.000001950355,0.00002481801,0.004584765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2556884,"threshold_uncertainty_score":0.9977499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05075768399777041,"score_gpt":0.314303096036568,"score_spread":0.2635454120387976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}