{"id":"W2064916443","doi":"10.1016/j.ymeth.2009.04.004","title":"Constraint counting on RNA structures: Linking flexibility and function","year":2009,"lang":"en","type":"review","venue":"Methods","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"McGill University","keywords":"Flexibility (engineering); Constraint (computer-aided design); Biomolecule; RNA; Covalent bond; Representation (politics); Function (biology); Computer science; Biological system; Chemistry; Nanotechnology; Mathematics; Biology; Materials science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001859621,0.0003539354,0.0007392132,0.00006107753,0.0001182143,0.00005687437,0.0001566686,0.0006176035,0.00002858161],"category_scores_gemma":[0.0003167677,0.0002806931,0.0002543045,0.0000694679,0.00006461718,0.00000183743,0.00006798572,0.000262111,0.000003262523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002235742,"about_ca_system_score_gemma":0.0001068404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002629101,"about_ca_topic_score_gemma":8.27228e-7,"domain_scores_codex":[0.9976975,0.0009528827,0.0003793092,0.0006275342,0.0001162592,0.0002265463],"domain_scores_gemma":[0.9990239,0.0001351652,0.0002673685,0.0004662635,0.00003875418,0.00006850562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001320172,0.000007677574,2.652676e-7,0.001316094,0.00006298905,0.000001129767,0.000004585781,6.407543e-7,0.005420561,0.00052682,0.00001674016,0.9926293],"study_design_scores_gemma":[0.00008103808,0.0002390407,0.000002322612,0.001625885,0.0002395938,0.0000271681,0.000007045097,0.000002447211,0.00863768,0.003708891,0.9851153,0.0003135732],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004791212,0.9212828,0.07624305,0.00000552455,0.000328592,0.0004106903,0.00001325081,0.00001955718,0.001648657],"genre_scores_gemma":[0.00003944417,0.9077708,0.09127871,0.0001423748,0.0004861441,0.00002825398,0.00008074584,0.00003455281,0.000138953],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9923157,"threshold_uncertainty_score":0.9999645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07754180206829028,"score_gpt":0.4029695147048203,"score_spread":0.32542771263653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}