{"id":"W2064920658","doi":"10.1074/jbc.m310448200","title":"Methanethiosulfonate Derivatives of Rhodamine and Verapamil Activate Human P-glycoprotein at Different Sites","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Canadian Institutes of Health Research","funders":"National Cancer Institute; National Institutes of Health","keywords":"Rhodamine; Rhodamine 123; P-glycoprotein; Chemistry; Transmembrane domain; Efflux; Biochemistry; Cysteine; Mutant; Transmembrane protein; Membrane; Multiple drug resistance; Enzyme; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000132895,0.0002693078,0.0001957432,0.0000868698,0.00007048538,0.0001652103,0.0001975948,0.0003475787,0.0006504243],"category_scores_gemma":[0.0002250131,0.0001667245,0.0003137848,0.0001289967,0.0001807682,0.0001622084,0.000138184,0.0003586409,0.0002406642],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001983657,"about_ca_system_score_gemma":0.0001367193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003839058,"about_ca_topic_score_gemma":0.0005054571,"domain_scores_codex":[0.99979,0.00005710228,0.00001882344,0.00003249298,0.00006333989,0.0000382426],"domain_scores_gemma":[0.9999107,0.00002733838,0.0000236306,0.00001299158,0.000009034622,0.00001627274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001072229,0.00001090743,0.00008988386,0.00001476467,0.000003506847,0.00004281187,0.000007624055,0.00002908583,0.999238,0.000046167,0.00001547513,0.0003947147],"study_design_scores_gemma":[0.00001494479,0.0002393154,0.001894338,0.000001606467,0.000006207268,0.0002827089,0.000008080462,0.0005512133,0.9963288,0.00002534647,0.0006437743,0.000003671205],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967229,0.0009169416,0.001203239,0.00006848807,0.00001732763,0.00002053396,0.00008478911,0.00003155835,0.000934231],"genre_scores_gemma":[0.9966217,0.0003660154,0.001744265,0.00003442564,0.000007263243,0.00002118824,0.0001735831,0.000008815891,0.001022742],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006504243,"threshold_uncertainty_score":0.002175927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03279540223674153,"score_gpt":0.2735089570922572,"score_spread":0.2407135548555157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}