{"id":"W2064921111","doi":"10.1002/cncr.26446","title":"Genetic sequence variants and the development of secondary primary cancers in patients with head and neck cancers","year":2011,"lang":"en","type":"article","venue":"Cancer","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec; Université Laval; Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Medicine; Internal medicine; Oncology; DNMT3B; Field cancerization; Hazard ratio; Head and neck cancer; Genotype; Proportional hazards model; Cancer; Gastroenterology; Methyltransferase; Genetics; Gene; Methylation; Biology; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009004261,0.0001284589,0.0003495846,0.00004380275,0.00006213261,0.000003279812,0.00004828166,0.00003456662,0.00006181948],"category_scores_gemma":[0.000008198816,0.00007867856,0.00001223875,0.0001245092,0.0003344516,0.00005050735,0.00004317751,0.0001177592,3.853067e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004108658,"about_ca_system_score_gemma":0.001308011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002687356,"about_ca_topic_score_gemma":0.005142533,"domain_scores_codex":[0.999186,0.00001995485,0.0002227437,0.0002205532,0.000151631,0.0001991117],"domain_scores_gemma":[0.99963,0.00002051374,0.00007630434,0.0001291358,0.00006901654,0.00007506753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001676768,0.00002383762,0.9126077,0.0002839061,0.000123877,0.00000546903,0.01303209,0.000003065412,0.00006510975,0.00001538515,0.0001112526,0.0720515],"study_design_scores_gemma":[0.006502491,0.0001794149,0.9916687,0.0005118852,0.00004074148,0.000001923956,0.0001871828,0.00001137288,0.0002006153,0.00001596587,0.0005763166,0.000103413],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990864,0.00524309,0.000006313924,0.00009185796,0.00008902689,0.0004200439,0.00001555257,0.000006989089,0.00326312],"genre_scores_gemma":[0.9963567,0.001025012,0.001763275,0.0006222015,0.00002142848,0.0001239075,0.00000191445,0.00001329449,0.00007230583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07906094,"threshold_uncertainty_score":0.4062496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02863171604622831,"score_gpt":0.2606302106872857,"score_spread":0.2319984946410574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}