{"id":"W2064927794","doi":"10.1097/coc.0b013e3181beac33","title":"A Multicenter Phase II Clinical Trial of Lapatinib (GW572016) in Hormonally Untreated Advanced Prostate Cancer","year":2010,"lang":"en","type":"article","venue":"American Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Cancer Centre","funders":"National Cancer Institute","keywords":"Lapatinib; Medicine; Internal medicine; Prostate cancer; Rash; Oncology; Clinical endpoint; Cancer; Prostate-specific antigen; Breast cancer; Population; Phases of clinical research; Adverse effect; Clinical trial; Trastuzumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003874428,0.0002167505,0.002449996,0.0002486719,0.00004118352,0.000005892496,0.0002697436,0.0002596941,0.0002712481],"category_scores_gemma":[0.003630958,0.0001416124,0.0006352985,0.0004241288,0.001675789,0.0001221169,0.00009623991,0.002151007,0.000007726986],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001105897,"about_ca_system_score_gemma":0.003308357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001446354,"about_ca_topic_score_gemma":0.0002591468,"domain_scores_codex":[0.9940842,0.0007513135,0.00385288,0.0003527142,0.0004984225,0.0004604249],"domain_scores_gemma":[0.9930912,0.002387189,0.002738827,0.0003189443,0.0008469002,0.0006169893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3591224,0.008830518,0.08209997,0.00001116623,0.000329092,0.0003881997,0.0001685477,0.000001827981,0.001248582,0.000007852894,0.0003177004,0.5474741],"study_design_scores_gemma":[0.5700669,0.2572074,0.1219038,0.0002310429,0.0004347929,0.00007260865,0.0003575606,0.0001275472,0.0005688291,0.00006785093,0.04876099,0.0002007788],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887893,0.0002263889,0.000006411342,0.007590886,0.00163556,0.0009221816,0.00002627715,0.000009870896,0.0007931868],"genre_scores_gemma":[0.9892575,0.004097703,0.004309431,0.0007675219,0.001008451,0.0000413462,0.00001005228,0.0000294124,0.0004785531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5472733,"threshold_uncertainty_score":0.9345175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09440197135542061,"score_gpt":0.5517576730823424,"score_spread":0.4573557017269217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}