{"id":"W2064941911","doi":"10.1039/b817954a","title":"Preparation of 1-aryl-substituted isoindoline derivatives by sequential Morita–Baylis–Hillman and intramolecular Diels–Alder reactions","year":2009,"lang":"en","type":"article","venue":"Organic & Biomolecular Chemistry","topic":"Synthetic Organic Chemistry Methods","field":"Chemistry","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Info-communications Media Development Authority","keywords":"Chemistry; Nitrile; Propargyl; Intramolecular force; Isoindoline; Aryl; Baylis–Hillman reaction; Aldimine; Isocyanate; Diels–Alder reaction; Medicinal chemistry; Organic chemistry; Adduct; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002380874,0.0005273989,0.0005385686,0.00004107469,0.0001582252,0.00006841582,0.0004258987,0.0005100348,0.002256778],"category_scores_gemma":[0.0005981685,0.0005932888,0.0001742224,0.0004345622,0.0003454775,0.0001549818,0.0001341748,0.0004087871,0.000007583422],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001596766,"about_ca_system_score_gemma":0.000171283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002537536,"about_ca_topic_score_gemma":9.447925e-7,"domain_scores_codex":[0.9973099,0.00003283525,0.0007983782,0.0008860512,0.0004802769,0.0004925071],"domain_scores_gemma":[0.9980415,0.00007735896,0.0004224589,0.001003859,0.0001777468,0.0002771477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006812268,0.0003170186,0.00004853365,0.0003093701,0.0001595443,0.00003622066,0.0002050671,6.225058e-7,0.9977477,0.0000261243,0.0002657295,0.000815967],"study_design_scores_gemma":[0.001035664,0.00003226418,0.00003261071,0.0001372299,0.0001431835,0.0002831305,0.0002094448,0.0001407469,0.9954084,0.0003126492,0.001712478,0.0005522191],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9006132,0.001680682,0.09033087,0.0006722263,0.00007999614,0.0002081417,0.0001195838,0.0002975182,0.005997735],"genre_scores_gemma":[0.9954668,0.000154542,0.003134779,0.00006704263,0.0001808656,0.00001501569,0.0003644412,0.00007504684,0.0005414939],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09485352,"threshold_uncertainty_score":0.9996518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008268483204716655,"score_gpt":0.2831016924600561,"score_spread":0.2748332092553394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}