{"id":"W2064965832","doi":"10.1095/biolreprod.105.046821","title":"Sperm from Mice Genetically Deficient for the PCSK4 Proteinase Exhibit Accelerated Capacitation, Precocious Acrosome Reaction, Reduced Binding to Egg Zona Pellucida, and Impaired Fertilizing Ability1","year":2005,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Sperm and Testicular Function","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Ottawa Hospital; University of Ottawa","funders":"","keywords":"Capacitation; Sperm; Zona pellucida; Acrosome reaction; Biology; Acrosome; Andrology; Cell biology; Epididymis; Oocyte; Genetics; Embryo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003112582,0.001347007,0.0006813107,0.001466164,0.0003101261,0.000453998,0.0006314998,0.0007921926,0.004836277],"category_scores_gemma":[0.000323373,0.0006083067,0.0004766774,0.0004834083,0.0006962612,0.0003529122,0.0004745715,0.0009937718,0.001258071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004144392,"about_ca_system_score_gemma":0.0002961268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007894028,"about_ca_topic_score_gemma":0.001487011,"domain_scores_codex":[0.9996552,0.00002831745,0.00005191566,0.00008236712,0.0001294077,0.00005275393],"domain_scores_gemma":[0.999426,0.00007675136,0.0002413559,0.0000568053,0.00005205385,0.0001470324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001505985,0.00001846125,0.0004664838,0.00006284793,0.00001760585,0.0001401215,0.00002163202,0.00004006521,0.9975529,0.0001290052,0.00007781442,0.001322542],"study_design_scores_gemma":[0.00009391868,0.0004902854,0.0157103,0.00001227316,0.00008484036,0.001965266,0.00003376284,0.000401886,0.9768449,0.0001375289,0.004204592,0.00002036178],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786175,0.003453942,0.009488161,0.0002805756,0.0001336092,0.0001183432,0.004976701,0.0009072646,0.002023985],"genre_scores_gemma":[0.9511005,0.003559754,0.0103527,0.0001486072,0.00006082145,0.0002073074,0.008982699,0.000346508,0.02524113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004836277,"threshold_uncertainty_score":0.01617903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04196258125648967,"score_gpt":0.2959714423726016,"score_spread":0.254008861116112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}