{"id":"W2064965832","doi":"10.1095/biolreprod.105.046821","title":"Sperm from Mice Genetically Deficient for the PCSK4 Proteinase Exhibit Accelerated Capacitation, Precocious Acrosome Reaction, Reduced Binding to Egg Zona Pellucida, and Impaired Fertilizing Ability1","year":2005,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Sperm and Testicular Function","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Ottawa Hospital; University of Ottawa","funders":"","keywords":"Capacitation; Sperm; Zona pellucida; Acrosome reaction; Biology; Acrosome; Andrology; Cell biology; Epididymis; Oocyte; Genetics; Embryo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006138562,0.0001596973,0.000249919,0.0001088782,0.0002158382,0.00001584372,0.00005615562,0.0001515936,0.00002640428],"category_scores_gemma":[0.0019957,0.0001208063,0.00007100814,0.0002363744,0.0001716961,0.00008257884,0.00002510864,0.0001234909,0.00001350278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001349148,"about_ca_system_score_gemma":0.00007260193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002396867,"about_ca_topic_score_gemma":0.00004101095,"domain_scores_codex":[0.9984555,0.00007507868,0.0004138468,0.0007197703,0.0001111172,0.0002247418],"domain_scores_gemma":[0.9986855,0.00015911,0.0001693116,0.0004539446,0.0004480187,0.00008416001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007050419,0.0001344327,0.004675271,0.00004056502,0.0000619741,3.488708e-7,0.0008734746,0.00004061828,0.945205,0.00002677512,0.0001195229,0.04811702],"study_design_scores_gemma":[0.001160745,0.000917879,0.2482847,0.00006477909,0.000198821,0.00009595586,0.0007170097,0.0006143859,0.7440033,0.0002246961,0.003540815,0.0001769442],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881519,0.001623212,0.002193735,0.005460194,0.0004798309,0.001969204,0.00002008167,0.00008014427,0.00002169034],"genre_scores_gemma":[0.9914998,0.00007134603,0.007249915,0.00007227514,0.0006696936,0.0001627829,0.0001190139,0.00002021797,0.0001349555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2436094,"threshold_uncertainty_score":0.4926338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04196258125648967,"score_gpt":0.2959714423726016,"score_spread":0.254008861116112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}