{"id":"W2064971374","doi":"10.1074/jbc.m205324200","title":"NRAGE, a p75 Neurotrophin Receptor-interacting Protein, Induces Caspase Activation and Cell Death through a JNK-dependent Mitochondrial Pathway","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":154,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada); McGill University; Montreal Neurological Institute and Hospital","funders":"National Cancer Institute; Killam Trusts","keywords":"Programmed cell death; Cell biology; Low-affinity nerve growth factor receptor; Cytosol; Apoptosis; Neurotrophin; Kinase; Caspase; Receptor; Signal transduction; Cancer research; Chemistry; Biology; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000123868,0.0001869072,0.0002088134,0.00001659619,0.00009270097,0.00004740157,0.0001379519,0.0003194077,0.0001676646],"category_scores_gemma":[0.0002249257,0.0001339067,0.0001249276,0.00004495745,0.00004147774,0.00001503917,0.00008677853,0.0003020033,0.000002302639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002553121,"about_ca_system_score_gemma":0.0000219489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000494052,"about_ca_topic_score_gemma":2.502721e-7,"domain_scores_codex":[0.9989112,0.00006656039,0.00038705,0.0002776941,0.0001655972,0.0001918847],"domain_scores_gemma":[0.9991561,0.00002668941,0.0004549805,0.0001394876,0.0001196998,0.0001030376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001801587,0.0001414475,0.00005532609,0.00002602451,0.00002081086,0.0000220592,0.00004503728,0.0000283654,0.997673,0.000004443547,0.0001777889,0.001625588],"study_design_scores_gemma":[0.0007600582,0.000480577,0.00008973497,0.00005094033,0.0000105844,0.0001435961,0.00008796466,0.0000582573,0.9941243,0.00008473101,0.003943682,0.0001655574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997399,0.0004967923,0.00096942,0.0001548803,0.0001597837,0.0001427773,0.000006208151,0.000007401964,0.000663768],"genre_scores_gemma":[0.9957247,0.000335894,0.00214341,0.00006941803,0.0009695368,0.000007529699,0.00001864232,0.00001345108,0.0007174506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003765893,"threshold_uncertainty_score":0.5460557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02887940626967054,"score_gpt":0.239851060657641,"score_spread":0.2109716543879705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}