{"id":"W2064996695","doi":"10.1016/j.celrep.2014.07.050","title":"Invadopodia Are Required for Cancer Cell Extravasation and Are a Therapeutic Target for Metastasis","year":2014,"lang":"en","type":"article","venue":"Cell Reports","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":400,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; University of California, San Diego; Canada Research Chairs; National Institutes of Health; Prostate Cancer Canada; Canadian Cancer Society Research Institute; Alberta Cancer Foundation; Movember Foundation","keywords":"Invadopodia; Extravasation; Cortactin; Intravasation; Metastasis; Cancer cell; Cancer; Cancer research; Stroma; Medicine; Cell; Pathology; Cell biology; Biology; Cytoskeleton; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002183548,0.00012589,0.0001464344,0.00002030257,0.0001059191,0.00003241215,0.0000446318,0.00009992642,0.00002694312],"category_scores_gemma":[0.00005430438,0.0001201059,0.0001096751,0.00002391042,0.0000152815,0.000006538992,0.00002588259,0.00003247439,5.108362e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000016509,"about_ca_system_score_gemma":0.00003708777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003139945,"about_ca_topic_score_gemma":0.0001300817,"domain_scores_codex":[0.9991695,0.0000215137,0.0002219787,0.0003563525,0.00006059758,0.0001700898],"domain_scores_gemma":[0.9991974,0.00001963561,0.0003075516,0.000273927,0.0001372056,0.00006429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004050273,0.00006401893,0.0004720647,0.00008727166,0.00003822409,0.000001818935,0.00003125454,0.00002500713,0.9920207,0.00004837161,0.004566297,0.002604529],"study_design_scores_gemma":[0.0002403533,0.0001500899,0.0001266074,0.000007967908,0.00005979197,0.00000985688,0.00009146213,0.0006511696,0.6298372,0.0007080515,0.3679863,0.0001311094],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.766186,0.01570288,0.2121322,0.0004214495,0.00149113,0.001764125,0.0001638966,0.00003423376,0.002104058],"genre_scores_gemma":[0.9946752,0.0003638341,0.00178243,0.0002471653,0.0002095423,0.0002739154,0.000228039,0.00003131393,0.002188513],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.36342,"threshold_uncertainty_score":0.4897775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02116623443281193,"score_gpt":0.2625527301797186,"score_spread":0.2413864957469067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}