{"id":"W2064996695","doi":"10.1016/j.celrep.2014.07.050","title":"Invadopodia Are Required for Cancer Cell Extravasation and Are a Therapeutic Target for Metastasis","year":2014,"lang":"en","type":"article","venue":"Cell Reports","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":400,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; University of California, San Diego; Canada Research Chairs; National Institutes of Health; Prostate Cancer Canada; Canadian Cancer Society Research Institute; Alberta Cancer Foundation; Movember Foundation","keywords":"Invadopodia; Extravasation; Cortactin; Intravasation; Metastasis; Cancer cell; Cancer; Cancer research; Stroma; Medicine; Cell; Pathology; Cell biology; Biology; Cytoskeleton; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009267485,0.0002578638,0.0002303742,0.0001666048,0.0002792157,0.0005037899,0.000154902,0.0003029541,0.001271012],"category_scores_gemma":[0.0001399034,0.0001685042,0.0002004613,0.00009362066,0.0002822366,0.000324021,0.0002230939,0.0007027552,0.0003907111],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003887565,"about_ca_system_score_gemma":0.0003212965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001080288,"about_ca_topic_score_gemma":0.001234478,"domain_scores_codex":[0.9999163,0.000009891488,0.000005765023,0.00001452925,0.00003262711,0.00002087508],"domain_scores_gemma":[0.9998893,0.00001008865,0.00004596532,0.0000108799,0.00001456973,0.00002923637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007224402,0.00001305555,0.0003413202,0.0000467152,0.000004028014,0.00009026189,0.00001319365,0.00008861057,0.9961417,0.0007610765,0.0001171495,0.0023107],"study_design_scores_gemma":[0.00002328651,0.0001899614,0.01429551,0.00001235457,0.00002339036,0.001065014,0.00008165478,0.001221442,0.9644741,0.000514471,0.01808759,0.00001121454],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9581937,0.01679392,0.01630715,0.0008122735,0.0001239406,0.00008289493,0.0008084392,0.0005228172,0.006354986],"genre_scores_gemma":[0.9876574,0.004222415,0.004171166,0.00007277473,0.0000153181,0.00002967228,0.0003650255,0.00003053836,0.003435661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001271012,"threshold_uncertainty_score":0.004251957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02116623443281193,"score_gpt":0.2625527301797186,"score_spread":0.2413864957469067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}