{"id":"W2065020908","doi":"10.1002/cbic.201200493","title":"Two Synthetic Antibodies that Recognize and Neutralize Distinct Proteolytic Forms of the Ebola Virus Envelope Glycoprotein","year":2012,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institute of General Medical Sciences; U.S. Public Health Service","keywords":"Ebola virus; Filoviridae; Viral envelope; Epitope; Viral entry; Glycoprotein; Antibody; Proteases; Virology; Proteolysis; Lipid bilayer fusion; Chemistry; Endosome; Biology; Virus; Biochemistry; Viral replication; Cell; Paramyxoviridae; Enzyme; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006083493,0.001307636,0.0008154581,0.0005863383,0.0001624558,0.0005419251,0.00119676,0.001676431,0.001021859],"category_scores_gemma":[0.0008790407,0.0003581962,0.0005433914,0.0004067832,0.000399176,0.0005094016,0.00056631,0.001318814,0.0005374966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001044948,"about_ca_system_score_gemma":0.0004176783,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005288316,"about_ca_topic_score_gemma":0.0005821185,"domain_scores_codex":[0.999082,0.0001464361,0.00007534046,0.0002210719,0.0002311726,0.0002439653],"domain_scores_gemma":[0.9994509,0.0001147823,0.000161238,0.00004583392,0.0001255232,0.0001017908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001630102,0.0001416042,0.0001818958,0.00009596245,0.00001915903,0.00006148952,0.00001900224,0.0001492386,0.9949461,0.0001638259,0.00006613821,0.00399268],"study_design_scores_gemma":[0.0002612401,0.002730859,0.004241274,0.00004022007,0.0001097956,0.001899313,0.00003703183,0.002303621,0.9811419,0.0001454786,0.007060839,0.00002838755],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9399048,0.01067893,0.04348992,0.000313306,0.0001826379,0.0008074807,0.0007002406,0.000271426,0.003651298],"genre_scores_gemma":[0.9513597,0.003593725,0.0379617,0.0007577673,0.00009660759,0.0006772188,0.002596727,0.0000389669,0.00291755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001676431,"threshold_uncertainty_score":0.007581651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03599692101445832,"score_gpt":0.3098694211088102,"score_spread":0.2738725000943519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}