{"id":"W2065030089","doi":"10.1073/pnas.1106351108","title":"Hypoxia-induced transcriptional repression of the melanoma-associated oncogene <i>MITF</i>","year":2011,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health; Dr. Miriam and Sheldon G. Adelson Medical Research Foundation; Melanoma Research Alliance","keywords":"Microphthalmia-associated transcription factor; Melanoma; Transcription factor; Biology; Cancer research; Melanocyte; Oncogene; IRF4; Cell biology; Ectopic expression; Cell growth; Molecular biology; Cell culture; Cell; Cell cycle; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007070921,0.00006485284,0.00008796313,0.00003468523,0.0001122197,0.000004049572,0.0005423236,0.0001003207,0.00001493839],"category_scores_gemma":[0.0002532157,0.00003791179,0.00009700642,0.0002434077,0.0002981168,0.00001611417,0.00008019298,0.00006483807,2.57555e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009741882,"about_ca_system_score_gemma":0.00003660327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008390505,"about_ca_topic_score_gemma":2.529883e-7,"domain_scores_codex":[0.998859,0.0000140237,0.0002581384,0.0001697652,0.0006135671,0.00008550892],"domain_scores_gemma":[0.9993407,0.00001424907,0.0004087007,0.00001252307,0.0002060437,0.00001779953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002950285,0.00005344682,0.007842207,0.00001081328,0.00001757525,1.058567e-9,0.0001397002,0.000005212056,0.9877827,0.003693803,0.0003267325,0.00009833032],"study_design_scores_gemma":[0.0001701048,0.00007418636,0.1506724,0.000034795,0.00001129638,0.000002364187,0.00007223937,0.00003329959,0.8443837,0.004444577,0.0000619502,0.00003906102],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910712,0.00008424103,0.000001307326,0.0003259795,0.00004045674,0.000116862,0.00001710677,0.000002068856,0.008340805],"genre_scores_gemma":[0.9992731,0.00001976573,0.0003488441,0.0001393216,0.00004035321,0.000005504558,7.174699e-7,0.000002943659,0.0001695024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.143399,"threshold_uncertainty_score":0.1545998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06509353680339493,"score_gpt":0.292259326986709,"score_spread":0.2271657901833141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}