{"id":"W2065053204","doi":"10.1016/j.cellsig.2010.09.011","title":"SHP-1 inhibits β-catenin function by inducing its degradation and interfering with its association with TATA-binding protein","year":2010,"lang":"en","type":"article","venue":"Cellular Signalling","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"Canada Research Chairs; Université Laval; Université de Montréal; Natural Sciences and Engineering Research Council of Canada; Université de Sherbrooke; Canadian Institutes of Health Research","keywords":"Tyrosine; Protein tyrosine phosphatase; Tyrosine phosphorylation; Phosphorylation; Catenin; Transactivation; Beta-catenin; Ectopic expression; Proto-oncogene tyrosine-protein kinase Src; Cell biology; SH2 domain; Chemistry; Biology; Cancer research; Biochemistry; Signal transduction; Transcription factor; Wnt signaling pathway; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002921219,0.0005756746,0.0003835707,0.0003764213,0.0004163772,0.0005328447,0.0005219643,0.0004696928,0.002491947],"category_scores_gemma":[0.0002281192,0.0003265939,0.0004916239,0.0003229888,0.0005306107,0.0003125684,0.0003358449,0.001510003,0.0007968222],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007840519,"about_ca_system_score_gemma":0.0004621452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001214123,"about_ca_topic_score_gemma":0.001377085,"domain_scores_codex":[0.9996779,0.00005211928,0.00002623981,0.0000486335,0.00006888838,0.0001262511],"domain_scores_gemma":[0.9998412,0.00004768117,0.00003861902,0.00002311981,0.00001321108,0.00003616746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002100057,0.00006431138,0.0001188333,0.00004986413,0.0000122869,0.00006224523,0.00001461229,0.00009630566,0.9979637,0.0002245491,0.0001461386,0.001037271],"study_design_scores_gemma":[0.00002378813,0.0001066812,0.001106421,0.000002632066,0.000009149207,0.0001264335,0.00001336178,0.0006601945,0.9962691,0.00004296246,0.00163582,0.000003520656],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855204,0.005120685,0.005438508,0.0004794143,0.0001449536,0.00004884545,0.0006064425,0.0002005404,0.002440075],"genre_scores_gemma":[0.9923562,0.001414283,0.001811879,0.0000895479,0.00003017359,0.00005961997,0.0009837957,0.00003132552,0.003223234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002491947,"threshold_uncertainty_score":0.008336425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007095547896593516,"score_gpt":0.1873229088793148,"score_spread":0.1802273609827213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}