{"id":"W2065053204","doi":"10.1016/j.cellsig.2010.09.011","title":"SHP-1 inhibits β-catenin function by inducing its degradation and interfering with its association with TATA-binding protein","year":2010,"lang":"en","type":"article","venue":"Cellular Signalling","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"Canada Research Chairs; Université Laval; Université de Montréal; Natural Sciences and Engineering Research Council of Canada; Université de Sherbrooke; Canadian Institutes of Health Research","keywords":"Tyrosine; Protein tyrosine phosphatase; Tyrosine phosphorylation; Phosphorylation; Catenin; Transactivation; Beta-catenin; Ectopic expression; Proto-oncogene tyrosine-protein kinase Src; Cell biology; SH2 domain; Chemistry; Biology; Cancer research; Biochemistry; Signal transduction; Transcription factor; Wnt signaling pathway; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004572831,0.0002341713,0.0001585363,0.00007246063,0.0002099553,0.0001248108,0.0001101735,0.0002275232,0.00003158435],"category_scores_gemma":[0.00004757398,0.0002049895,0.00002683714,0.0001578363,0.00002620638,0.00003917433,0.00005461829,0.000319523,0.000009203607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004637902,"about_ca_system_score_gemma":0.00007898853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000609169,"about_ca_topic_score_gemma":0.00002343677,"domain_scores_codex":[0.9986753,0.00004092134,0.0002297224,0.0004813868,0.0002626416,0.000310047],"domain_scores_gemma":[0.9993602,0.00001439785,0.0002342935,0.000110249,0.0001938233,0.00008701591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001388347,0.00001827465,0.003236744,0.00003985373,0.00008760735,0.000002108894,0.00009824092,0.00009031369,0.9955357,0.00001811902,0.00008706526,0.0006471131],"study_design_scores_gemma":[0.0006208979,0.0002074138,0.00006982409,0.000143418,0.00004663695,0.000006114272,0.00008440985,0.0003374858,0.9968959,0.000006036792,0.001251997,0.0003298851],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832144,0.0004701668,0.01560241,0.00006690068,0.0001243892,0.0003338478,0.000005453743,0.00003656547,0.000145809],"genre_scores_gemma":[0.9953052,0.00002388049,0.001270001,0.00003150536,0.0001813609,0.00007129423,0.0002996087,0.00005047407,0.002766675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01433241,"threshold_uncertainty_score":0.8359227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007095547896593516,"score_gpt":0.1873229088793148,"score_spread":0.1802273609827213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}