{"id":"W2065062347","doi":"10.1016/j.vaccine.2009.05.095","title":"Modified vaccinia Ankara strains with identical coding sequences actually represent complex mixtures of viruses that determine the biological properties of each strain","year":2009,"lang":"en","type":"article","venue":"Vaccine","topic":"Poxvirus research and outbreaks","field":"Immunology and Microbiology","cited_by":64,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Genetics; Bavarian Nordic","keywords":"Biology; Vaccinia; Virology; Phenotype; Polyclonal antibodies; Virus; Strain (injury); Modified vaccinia Ankara; Embryo; Serial passage; Orthopoxvirus; Genetics; Gene; Antibody; Recombinant DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004340161,0.0002248454,0.0004955975,0.0001096544,0.000143809,0.00002186555,0.0005611471,0.0001714384,0.0003496703],"category_scores_gemma":[0.0002700574,0.0001086454,0.0001041082,0.0001675503,0.0002232084,0.00009966008,0.0001048628,0.0003184207,0.000009854637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001538231,"about_ca_system_score_gemma":0.00008301354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001582532,"about_ca_topic_score_gemma":0.00008657462,"domain_scores_codex":[0.9983963,0.0002559527,0.0004577612,0.0003133838,0.0001195768,0.0004570621],"domain_scores_gemma":[0.9990294,0.0001976341,0.0002067551,0.000403761,0.0001186467,0.0000437896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001328877,0.0001935029,0.00313059,0.00002707322,0.0001719127,0.00001392306,0.0005382636,0.0000144107,0.9895307,0.0007047555,0.0003409158,0.004005064],"study_design_scores_gemma":[0.001670637,0.00150296,0.1907368,0.0001045993,0.00004002661,0.00009250321,0.0005801346,0.00003584516,0.8045244,0.0002938129,0.0002391268,0.0001792166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966755,0.001536657,0.00009646279,0.0007852456,0.00003877041,0.0003904445,0.000105828,0.00004168812,0.0003294107],"genre_scores_gemma":[0.9993671,0.0001826722,0.00006675685,0.0002105424,0.00003104225,0.00001054827,0.00003776463,0.000008349708,0.00008519521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1876062,"threshold_uncertainty_score":0.4430431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1196178308335249,"score_gpt":0.3122708656767821,"score_spread":0.1926530348432572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}