{"id":"W2065062449","doi":"10.1006/bbrc.2000.2847","title":"Plasma Membrane Receptors for the Cancer-Regulating Progesterone Metabolites, 5α-Pregnane-3,20-dione and 3α-Hydroxy-4-pregnen-20-one in MCF-7 Breast Cancer Cells","year":2000,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Cytosol; Chemistry; MCF-7; Receptor; Metabolite; Dissociation constant; Steroid; Cancer cell; Hormone; Membrane; Steroid hormone; Endocrinology; Internal medicine; Biochemistry; Biology; Enzyme; Cancer; Human breast; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002415854,0.0002654327,0.0004913707,0.0002971695,0.0004076817,0.0006170427,0.0002970814,0.0003223544,0.002207771],"category_scores_gemma":[0.0002956551,0.0002851765,0.0003402978,0.0005183793,0.000278559,0.0004001899,0.0001548007,0.000780234,0.001196534],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009755475,"about_ca_system_score_gemma":0.0005125797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008694592,"about_ca_topic_score_gemma":0.007712963,"domain_scores_codex":[0.9996448,0.00005351666,0.00002031564,0.00003491298,0.0001332757,0.0001133233],"domain_scores_gemma":[0.9998695,0.00004394659,0.000009865815,0.000025392,0.00003067109,0.00002061199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002673202,0.00004029374,0.0002455467,0.00005600451,0.0000110956,0.0001608556,0.00009966912,0.0001244788,0.9958704,0.0005757491,0.0006811528,0.001867424],"study_design_scores_gemma":[0.00005837203,0.0004801857,0.01338062,0.00001686827,0.0000627101,0.001015155,0.0004025022,0.002027684,0.9585333,0.0003219955,0.02367328,0.00002727123],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9660897,0.01430631,0.004513524,0.001659889,0.0003460711,0.00006087892,0.004181325,0.0002732904,0.008568937],"genre_scores_gemma":[0.9648318,0.008524631,0.002166703,0.0003090923,0.00005497225,0.00006900044,0.007689587,0.00003480088,0.0163194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008694592,"threshold_uncertainty_score":0.01728797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03280553148447882,"score_gpt":0.332385594842967,"score_spread":0.2995800633584882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}