{"id":"W2065078219","doi":"10.1159/000360764","title":"Sustained Activation of Interferon Regulatory Factor 3 during Infection by Paramyxoviruses Requires MDA5","year":2014,"lang":"en","type":"article","venue":"Journal of Innate Immunity","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"MDA5; RIG-I; Gene knockdown; Interferon regulatory factors; Biology; Interferon; Innate immune system; Cell biology; Sendai virus; Transcription factor; Virology; Virus; Gene; RNA; RNA interference; Immunology; Immune system; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006330347,0.0001707622,0.0003951125,0.0003288196,0.0001601132,0.00001780932,0.00024069,0.0002139538,0.0002424636],"category_scores_gemma":[0.0007471919,0.0001399539,0.0001679531,0.0001287863,0.0001966604,0.0004251706,0.0001164208,0.0006174593,0.00001562502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001399213,"about_ca_system_score_gemma":0.00006840931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001974552,"about_ca_topic_score_gemma":0.000006780373,"domain_scores_codex":[0.9980267,0.000835476,0.0007540617,0.00009208538,0.00006860092,0.0002231244],"domain_scores_gemma":[0.9982101,0.0002428698,0.0008934182,0.0002624482,0.0003699319,0.00002123368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003150182,0.0001864006,0.002423069,0.00005549321,0.0002103198,5.752275e-7,0.0005319964,0.000007726731,0.9893069,0.00008331735,0.0008546289,0.003189362],"study_design_scores_gemma":[0.001383633,0.001151344,0.06706094,0.0001915726,0.00002429209,0.00006670882,0.0003387728,0.000002059054,0.9260207,0.00006669559,0.003572409,0.0001208027],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980366,0.0005795777,0.0003073172,0.00009266565,0.0006013531,0.00008012739,0.000006605838,0.0000218891,0.0002738249],"genre_scores_gemma":[0.9991149,0.0001672634,0.00001125493,0.00004275911,0.00003090516,0.000001494279,0.00001011546,0.00001663683,0.0006046798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06463788,"threshold_uncertainty_score":0.5707153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01241065252757205,"score_gpt":0.2550012655083131,"score_spread":0.2425906129807411,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}