{"id":"W2065078219","doi":"10.1159/000360764","title":"Sustained Activation of Interferon Regulatory Factor 3 during Infection by Paramyxoviruses Requires MDA5","year":2014,"lang":"en","type":"article","venue":"Journal of Innate Immunity","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"MDA5; RIG-I; Gene knockdown; Interferon regulatory factors; Biology; Interferon; Innate immune system; Cell biology; Sendai virus; Transcription factor; Virology; Virus; Gene; RNA; RNA interference; Immunology; Immune system; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002137601,0.0002826942,0.0002013087,0.000162766,0.0001779429,0.0003849117,0.0001669161,0.0002365301,0.0006931181],"category_scores_gemma":[0.0001389172,0.0001377145,0.0004401116,0.00008259319,0.000157818,0.0003773887,0.0003193908,0.0005690644,0.0003679489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004832183,"about_ca_system_score_gemma":0.0002138712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007757007,"about_ca_topic_score_gemma":0.0009711744,"domain_scores_codex":[0.9997917,0.00002616535,0.00002111425,0.00004099428,0.00004278113,0.00007728406],"domain_scores_gemma":[0.9999171,0.00001213067,0.00002396955,0.00001413046,0.00001265849,0.00001997539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005900548,0.000007422536,0.0002758771,0.00001708529,0.000002468921,0.00003084561,0.00001469107,0.00002848094,0.9989902,0.00008019918,0.00001529118,0.0004783991],"study_design_scores_gemma":[0.000008268419,0.000156077,0.01604811,0.00001032757,0.0000161417,0.0001752177,0.00007645218,0.001059988,0.9806083,0.00008681428,0.001747186,0.000007064521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910177,0.00260658,0.004882881,0.00007512314,0.00002862059,0.00002420925,0.0003386079,0.0000697111,0.0009565428],"genre_scores_gemma":[0.9968869,0.0004872569,0.001337609,0.00003971336,0.000005494911,0.00002324522,0.0003828779,0.000008645401,0.0008282194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007757007,"threshold_uncertainty_score":0.003506005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01241065252757205,"score_gpt":0.2550012655083131,"score_spread":0.2425906129807411,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}