{"id":"W2065097616","doi":"10.1016/j.febslet.2004.10.040","title":"Effect of IGF‐1 on the balance between autophagy of dysfunctional mitochondria and apoptosis","year":2004,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Institute of Infection and Immunity; University of Toronto","funders":"","keywords":"Autophagy; Mitochondrion; Mitochondrial DNA; Cell biology; Reactive oxygen species; Mitophagy; Apoptosis; Biology; Mitochondrial ROS; Programmed cell death; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001379205,0.0001030916,0.0001519079,0.00003052708,0.00004006063,0.000004048935,0.00009229531,0.00008610684,0.00003049987],"category_scores_gemma":[0.00009910439,0.00007143751,0.0000749738,0.00005501754,0.0001259572,0.000001842543,0.0000323185,0.00007633632,0.000009320019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006828279,"about_ca_system_score_gemma":0.00001570141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001572143,"about_ca_topic_score_gemma":0.000001681812,"domain_scores_codex":[0.9993558,0.0001042732,0.0001451168,0.0001899254,0.00009586102,0.0001090556],"domain_scores_gemma":[0.9995692,0.00008750118,0.00008344913,0.0002096791,0.00001990016,0.00003024729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001969201,0.00001138325,0.003608004,0.00002233406,0.00004345261,4.339097e-7,0.00002029581,0.00006445021,0.991711,0.000253887,0.003782175,0.0002856261],"study_design_scores_gemma":[0.0008629339,0.0008874338,0.004028565,0.00001671443,0.00002650653,0.000004173049,0.000003440356,0.000001669923,0.9904079,0.00002038277,0.003668573,0.00007165253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963185,0.00005213653,0.001206568,0.001524356,0.0003842256,0.0001551599,0.00002489758,0.000005151766,0.0003289625],"genre_scores_gemma":[0.9981126,0.00001230145,0.0001974713,0.001211694,0.0002997154,0.00001545446,0.00003796702,0.00000903184,0.0001037183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001794104,"threshold_uncertainty_score":0.2913137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006873581350010015,"score_gpt":0.2261083934301606,"score_spread":0.2192348120801506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}