{"id":"W2065125513","doi":"10.1021/jm401480r","title":"Discovery of an in Vivo Chemical Probe of the Lysine Methyltransferases G9a and GLP","year":2013,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":273,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institute of Mental Health; National Institutes of Health; National Institute of General Medical Sciences; Wellcome Trust","keywords":"Methyltransferase; In vivo; Chemistry; Lysine; Epigenetics; Histone H3; Biochemistry; Drug discovery; In vitro; Cell; Potency; Histone; Methylation; Amino acid; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002912517,0.00008756209,0.0002142985,0.00001979811,0.00001205662,0.00000729975,0.0001603345,0.000104932,0.00001732126],"category_scores_gemma":[0.0001897343,0.00005689009,0.00007368476,0.00007116942,0.0001802765,0.00001056111,0.00003354945,0.0001324961,2.980327e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000082745,"about_ca_system_score_gemma":0.00009969195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000302242,"about_ca_topic_score_gemma":0.000003363058,"domain_scores_codex":[0.9991313,0.000034763,0.0004230216,0.00009985918,0.000219987,0.00009103939],"domain_scores_gemma":[0.9993685,0.00002665813,0.0002490073,0.0001555063,0.0001447982,0.00005552784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006584186,0.00008597845,0.00581528,0.0001000881,0.00002459149,0.000001348891,0.00005925143,0.00002244714,0.9929962,0.000002164906,0.0000228186,0.0008039671],"study_design_scores_gemma":[0.0006002047,0.0001657978,0.005238778,0.0001049076,0.00003475897,0.00002876435,0.0001369615,0.00002496628,0.9932754,0.0002398206,0.00009381182,0.00005580067],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972433,0.002085428,0.0002401449,0.0001916539,0.00002951636,0.00005883775,0.000005161588,4.462122e-7,0.0001454871],"genre_scores_gemma":[0.9989998,0.0002952575,0.000463142,0.00002193313,0.0001634443,0.000001517493,0.000003097491,0.000006873437,0.00004496919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001790171,"threshold_uncertainty_score":0.2319911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006238017442721459,"score_gpt":0.240608136956996,"score_spread":0.2343701195142746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}