{"id":"W2065125513","doi":"10.1021/jm401480r","title":"Discovery of an in Vivo Chemical Probe of the Lysine Methyltransferases G9a and GLP","year":2013,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":273,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institute of Mental Health; National Institutes of Health; National Institute of General Medical Sciences; Wellcome Trust","keywords":"Methyltransferase; In vivo; Chemistry; Lysine; Epigenetics; Histone H3; Biochemistry; Drug discovery; In vitro; Cell; Potency; Histone; Methylation; Amino acid; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003298287,0.0004318914,0.0002484744,0.0002116301,0.0001907659,0.0002829104,0.0003690517,0.0006624918,0.001474016],"category_scores_gemma":[0.0003183696,0.0002221635,0.0002571822,0.0001392671,0.000308606,0.0003354302,0.000392692,0.0009140967,0.0003591533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000373555,"about_ca_system_score_gemma":0.0003539039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000413761,"about_ca_topic_score_gemma":0.0006442717,"domain_scores_codex":[0.9998565,0.00004067723,0.000005319987,0.00003653009,0.00003067885,0.00003026513],"domain_scores_gemma":[0.9998735,0.00002483888,0.00003603415,0.0000201336,0.0000186705,0.00002683757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001845847,0.00006774633,0.0001197812,0.00006885237,0.00001177041,0.00008547253,0.00002821433,0.000492783,0.9902997,0.0008808867,0.0002897643,0.007470327],"study_design_scores_gemma":[0.0000365238,0.0007578582,0.0003145135,0.000005321887,0.00001245019,0.000207342,0.00001162892,0.0005124772,0.989825,0.0001317546,0.00817775,0.000007330664],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9108615,0.006826657,0.0603806,0.001521483,0.0002612462,0.0003594787,0.001299634,0.0005044395,0.0179849],"genre_scores_gemma":[0.9642263,0.003665715,0.02259597,0.0005490176,0.00004394219,0.0001157859,0.000763409,0.00005325917,0.007986594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001474016,"threshold_uncertainty_score":0.004931092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006238017442721459,"score_gpt":0.240608136956996,"score_spread":0.2343701195142746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}