{"id":"W2065152431","doi":"10.1038/ni.1914","title":"The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88","year":2010,"lang":"en","type":"article","venue":"Nature Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":342,"is_retracted":false,"has_abstract":false,"ca_institutions":"Izaak Walton Killam Health Centre","funders":"National Center for Research Resources; National Institute of Allergy and Infectious Diseases; National Cancer Institute","keywords":"B-cell activating factor; Signal transducing adaptor protein; Immunoglobulin class switching; Signal transduction; Cell biology; Decoy; Receptor; Antibody; Transcription factor; Biology; Cancer research; B cell; Immunology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002432076,0.00027014,0.000223925,0.0002619395,0.0002616113,0.0006288089,0.0002427452,0.0004316173,0.001801516],"category_scores_gemma":[0.0003245209,0.0002665084,0.0002413326,0.0001415506,0.0002326316,0.0003929866,0.0007311114,0.001144563,0.001072357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004913136,"about_ca_system_score_gemma":0.000242328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001662501,"about_ca_topic_score_gemma":0.0002933329,"domain_scores_codex":[0.9996376,0.00005136205,0.00001999542,0.00004948087,0.0000803881,0.0001610986],"domain_scores_gemma":[0.999811,0.00002488061,0.00005557954,0.0000230256,0.00001923646,0.00006634191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004795774,0.00003420978,0.0007163422,0.00004382108,0.00001119142,0.0001748167,0.00003579889,0.0001053345,0.9919796,0.0005944876,0.0006333978,0.005191299],"study_design_scores_gemma":[0.0002336291,0.0005160797,0.04061394,0.00004238305,0.00007481692,0.001454359,0.000277232,0.004588167,0.934175,0.001672329,0.01632491,0.00002713661],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869024,0.002900389,0.003021043,0.0005414267,0.0002080117,0.00001932801,0.0002477137,0.0002358133,0.005923898],"genre_scores_gemma":[0.9952433,0.0007406624,0.001027912,0.0001200667,0.00006008575,0.00001601458,0.0002962905,0.00003209706,0.00246378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001801516,"threshold_uncertainty_score":0.006026685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004976055034526554,"score_gpt":0.2239967925701845,"score_spread":0.2190207375356579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}