{"id":"W2065173416","doi":"10.1006/jmbi.2001.4882","title":"Crystal structure of histidinol phosphate aminotransferase (HisC) from Escherichia coli, and its covalent complex with pyridoxal-5′-phosphate and l-histidinol phosphate","year":2001,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"Biotechnology Research Institute","funders":"Honjo International Scholarship Foundation; Brookhaven National Laboratory; Hawaii Invasive Species Council","keywords":"Chemistry; Histidine; Stereochemistry; Aldimine; Pyridoxal phosphate; Active site; Biochemistry; Cofactor; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002281877,0.0003888831,0.0005961492,0.0001928313,0.0004115394,0.0008490502,0.0007451756,0.00056734,0.001263176],"category_scores_gemma":[0.0004201532,0.000287001,0.0001471513,0.0005570663,0.0003548368,0.0002635397,0.0001918538,0.00141354,0.0002468626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001577687,"about_ca_system_score_gemma":0.0009136499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01109821,"about_ca_topic_score_gemma":0.008555989,"domain_scores_codex":[0.9998833,0.000009861144,0.000005803047,0.00002479798,0.00005122907,0.00002497413],"domain_scores_gemma":[0.9997579,0.00006461635,0.00004911638,0.00001055757,0.00004882282,0.00006887998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005131745,0.001913169,0.01890816,0.001265406,0.0003508112,0.00362925,0.0007512991,0.009654553,0.9050338,0.007116503,0.01338034,0.03286505],"study_design_scores_gemma":[0.001274871,0.001284555,0.09475578,0.0001246481,0.000410494,0.004163305,0.001351514,0.07114539,0.7833949,0.001588471,0.04033133,0.0001747648],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901227,0.003372211,0.00119838,0.0005962019,0.0001209102,0.00002884219,0.001214278,0.0001478072,0.00319869],"genre_scores_gemma":[0.986068,0.002156941,0.002634072,0.0002303839,0.00002310547,0.00002582049,0.004058802,0.00003797564,0.004764786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01109821,"threshold_uncertainty_score":0.02206719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01110901088677139,"score_gpt":0.2332604207998105,"score_spread":0.2221514099130391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}