{"id":"W2065179135","doi":"10.1038/cddis.2011.104","title":"OGX-427 inhibits tumor progression and enhances gemcitabine chemotherapy in pancreatic cancer","year":2011,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital","funders":"Ligue Contre le Cancer; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Association pour la Recherche sur les Tumeurs de la Prostate; Institut National Du Cancer; Association pour la Recherche sur le Cancer","keywords":"Gemcitabine; Hsp27; Cancer research; Pancreatic cancer; Gene knockdown; Cancer; Metastasis; Heat shock protein; Apoptosis; Chemotherapy; Cancer cell; Internal medicine; Biology; Medicine; Oncology; Hsp70","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001103162,0.0003207196,0.0003883205,0.0003142267,0.0001563278,0.0002779133,0.0001288633,0.0001747018,0.0008649918],"category_scores_gemma":[0.0001138516,0.0001398932,0.000184187,0.0002688935,0.0001676213,0.0001498101,0.0001873467,0.0005298821,0.0002025104],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002206167,"about_ca_system_score_gemma":0.0002798916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007757147,"about_ca_topic_score_gemma":0.00244701,"domain_scores_codex":[0.9999409,0.0000177558,0.000004890191,0.000006013466,0.00001334354,0.00001709584],"domain_scores_gemma":[0.9999573,0.000007750062,0.000007894421,0.000005647735,0.000002901109,0.00001854208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003478738,0.001334051,0.001796642,0.0001729735,0.00006167648,0.000193366,0.00007286669,0.001303409,0.9558383,0.0001902703,0.0005979774,0.03495982],"study_design_scores_gemma":[0.0008427565,0.02260192,0.03531539,0.00003984506,0.0001475257,0.0007434651,0.00011867,0.004371713,0.9248676,0.0001990781,0.01073081,0.00002127189],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964733,0.001556954,0.0002840924,0.00007318726,0.00002312837,0.00003003476,0.00008663133,0.00005655904,0.001416104],"genre_scores_gemma":[0.9945258,0.002568834,0.0006319621,0.00005435386,0.00001567505,0.00003775636,0.000426919,0.000020287,0.0017185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008649918,"threshold_uncertainty_score":0.002893627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01514460745142832,"score_gpt":0.2858418488578854,"score_spread":0.2706972414064571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}