{"id":"W2065179135","doi":"10.1038/cddis.2011.104","title":"OGX-427 inhibits tumor progression and enhances gemcitabine chemotherapy in pancreatic cancer","year":2011,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital","funders":"Ligue Contre le Cancer; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Association pour la Recherche sur les Tumeurs de la Prostate; Institut National Du Cancer; Association pour la Recherche sur le Cancer","keywords":"Gemcitabine; Hsp27; Cancer research; Pancreatic cancer; Gene knockdown; Cancer; Metastasis; Heat shock protein; Apoptosis; Chemotherapy; Cancer cell; Internal medicine; Biology; Medicine; Oncology; Hsp70","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000889865,0.0001225461,0.0001100007,0.00004103312,0.00004986324,0.0000172783,0.00006475312,0.00004846296,0.00005568087],"category_scores_gemma":[0.00004810973,0.0000998375,0.00002150464,0.00005606554,0.00007205795,0.0000062575,0.00007341786,0.00005944771,0.000002360689],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000804611,"about_ca_system_score_gemma":0.0001289555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006863505,"about_ca_topic_score_gemma":0.00002111525,"domain_scores_codex":[0.9991865,0.00004176436,0.0001123005,0.000320369,0.00009329993,0.0002457985],"domain_scores_gemma":[0.9993988,0.00000497541,0.00002395213,0.0001626303,0.00002917267,0.0003804513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001195613,0.0003127836,0.3081661,0.0003636348,0.0000140951,0.00005903619,0.0002249556,6.950351e-7,0.6716949,0.00002619274,0.0001915769,0.01775045],"study_design_scores_gemma":[0.001706276,0.0002936796,0.1497109,0.0001111379,0.00001600359,0.000003007745,0.00004252283,0.0001396172,0.8451892,0.0003273913,0.002201975,0.0002582273],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845709,0.01394281,0.00002790154,0.00008400124,0.00001582283,0.0003614359,0.00001339206,0.000007208178,0.0009764998],"genre_scores_gemma":[0.9958881,0.002997158,0.0002508609,0.000200357,0.00005988262,0.0001549416,0.0000178061,0.00001559959,0.000415308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1734944,"threshold_uncertainty_score":0.4071255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01514460745142832,"score_gpt":0.2858418488578854,"score_spread":0.2706972414064571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}