{"id":"W2065232590","doi":"10.1021/ja0167809","title":"Diazo Group Electrophilicity in Kinamycins and Lomaiviticin A:  Potential Insights into the Molecular Mechanism of Antibacterial and Antitumor Activity","year":2002,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Chemistry; Diazo; Electrophile; Reactivity (psychology); Mechanism (biology); Combinatorial chemistry; Salt (chemistry); Antibacterial activity; Stereochemistry; Antibiotics; Antibacterial agent; Organic chemistry; Bacteria; Biochemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001170372,0.0001832582,0.0001000952,0.0001387159,0.0001452317,0.0001818989,0.0001563439,0.0003413986,0.001242175],"category_scores_gemma":[0.0001447119,0.00007804469,0.0001448382,0.00005602665,0.000292953,0.0002927355,0.0001590348,0.0002585457,0.0001778292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002684109,"about_ca_system_score_gemma":0.0001314967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001798257,"about_ca_topic_score_gemma":0.0001991079,"domain_scores_codex":[0.9999712,0.000008262248,0.000001471711,0.000005810601,0.000005552685,0.000007779575],"domain_scores_gemma":[0.9999443,0.00001840589,0.00001798647,0.000004203916,0.000004585972,0.00001047324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000220723,0.00002610883,0.0006174314,0.00005544689,0.000006304884,0.0002743921,0.0000491942,0.0007184851,0.9896098,0.00513921,0.00003111552,0.003251775],"study_design_scores_gemma":[0.000056251,0.0007017324,0.003311788,0.00001098272,0.00001977826,0.001075397,0.00008394453,0.002817101,0.9851404,0.003678561,0.003087511,0.00001649674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895741,0.001393817,0.004858435,0.0001758238,0.00001406213,0.00001410944,0.00004974401,0.00002612493,0.003893709],"genre_scores_gemma":[0.9983122,0.0003075422,0.0007131904,0.0000212487,0.00000343236,0.000006707871,0.00002140309,0.000002392837,0.0006118256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001242175,"threshold_uncertainty_score":0.004155457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004818925041478946,"score_gpt":0.2077424566489996,"score_spread":0.2029235316075206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}