{"id":"W2065301559","doi":"10.1038/cr.2012.58","title":"K48-linked ubiquitination and protein degradation regulate 53BP1 recruitment at DNA damage sites","year":2012,"lang":"en","type":"article","venue":"Cell Research","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Biology; DNA damage; Ubiquitin; DNA repair; DNA; Cell biology; Genetics; Molecular biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003290385,0.0004039114,0.0005926314,0.0003649114,0.0009473239,0.001517419,0.0004310581,0.0007030288,0.005677529],"category_scores_gemma":[0.0005285262,0.0004925238,0.0005918384,0.0002530123,0.0004586007,0.001558675,0.0008698907,0.0008327343,0.003254223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001331599,"about_ca_system_score_gemma":0.0003721864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001142324,"about_ca_topic_score_gemma":0.002030197,"domain_scores_codex":[0.9995609,0.00002880366,0.00003324906,0.0001156802,0.00006584539,0.0001954217],"domain_scores_gemma":[0.999663,0.00003214553,0.00008437857,0.00004474876,0.00007783585,0.0000979863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000937814,0.00007062154,0.002252052,0.00008249238,0.00001755527,0.0001439479,0.00006611201,0.0001433858,0.9894444,0.0006107444,0.0005816438,0.005649171],"study_design_scores_gemma":[0.0000542023,0.0001248981,0.06230285,0.00001398647,0.00002018809,0.0003943951,0.0002128367,0.002487274,0.9301039,0.0005401435,0.003720754,0.00002456258],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982294,0.005986719,0.006170523,0.000650001,0.0001672449,0.00003340238,0.0005242502,0.0002495662,0.003924292],"genre_scores_gemma":[0.9930272,0.0008172621,0.001156857,0.0000746406,0.00002675889,0.00002432069,0.0003484716,0.0000545823,0.004469966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005677529,"threshold_uncertainty_score":0.0189932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1108444691788452,"score_gpt":0.3607393949519573,"score_spread":0.2498949257731122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}