{"id":"W2065346958","doi":"10.1002/iub.1011","title":"The SOCS box—Adapting proteins for ubiquitination and proteasomal degradation","year":2012,"lang":"en","type":"review","venue":"IUBMB Life","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"Tellabs (Canada)","funders":"National Health and Medical Research Council; National Medical Research Council; State Government of Victoria; Australian Government","keywords":"F-box protein; Ubiquitin ligase; Ubiquitin; Signal transducing adaptor protein; Ankyrin repeat; Cell biology; Proteasome; Scaffold protein; SH2 domain; Suppressor of cytokine signalling; Biology; Ubiquitin-Protein Ligases; Biochemistry; Signal transduction; SOCS3; Gene; STAT3; Proto-oncogene tyrosine-protein kinase Src","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003629855,0.0009354273,0.001009669,0.001345586,0.0002479983,0.0008156893,0.0007625308,0.0007836255,0.003183417],"category_scores_gemma":[0.0002066279,0.0002131107,0.0003072353,0.001174852,0.0004521745,0.001086746,0.0006355661,0.001031903,0.004180153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005800497,"about_ca_system_score_gemma":0.0006765875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003109889,"about_ca_topic_score_gemma":0.0005507578,"domain_scores_codex":[0.9998801,0.00001600523,0.00001615373,0.00002221498,0.00004714952,0.0000182621],"domain_scores_gemma":[0.9999073,0.00001922773,0.00002115543,0.000006136281,0.00002409289,0.00002223914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006659824,0.00004458352,0.0001258146,0.00577399,0.00005396695,0.0002845336,0.00003394522,0.0002794302,0.008037074,0.005415737,0.02929414,0.9505903],"study_design_scores_gemma":[0.00001207857,0.00004746786,0.0004674159,0.0004460639,0.00001937461,0.001709713,0.00002041653,0.00005026478,0.001740495,0.001480252,0.9939966,0.000009833285],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003322983,0.9966784,0.0004467713,0.0001872745,0.0002277736,0.000007044865,0.00002971268,0.00002823318,0.002062618],"genre_scores_gemma":[0.002539565,0.9943454,0.0004781232,0.0002026109,0.0002318961,0.00001381607,0.0001013431,0.000004738813,0.002082456],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003183417,"threshold_uncertainty_score":0.01064962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06532433896495135,"score_gpt":0.3195061937847813,"score_spread":0.25418185481983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}