{"id":"W2065346958","doi":"10.1002/iub.1011","title":"The SOCS box—Adapting proteins for ubiquitination and proteasomal degradation","year":2012,"lang":"en","type":"review","venue":"IUBMB Life","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"Tellabs (Canada)","funders":"National Health and Medical Research Council; National Medical Research Council; State Government of Victoria; Australian Government","keywords":"F-box protein; Ubiquitin ligase; Ubiquitin; Signal transducing adaptor protein; Ankyrin repeat; Cell biology; Proteasome; Scaffold protein; SH2 domain; Suppressor of cytokine signalling; Biology; Ubiquitin-Protein Ligases; Biochemistry; Signal transduction; SOCS3; Gene; STAT3; Proto-oncogene tyrosine-protein kinase Src","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009257743,0.0003363166,0.0004322427,0.00003916594,0.0004433203,0.0001170968,0.0002408483,0.0004340536,0.000004333353],"category_scores_gemma":[0.0005857436,0.0002377477,0.0002305256,0.00007396381,0.00008467498,0.000008447296,0.0001441263,0.0001991656,0.000009758541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002778233,"about_ca_system_score_gemma":0.0003130162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006258167,"about_ca_topic_score_gemma":0.00001504968,"domain_scores_codex":[0.998367,0.0002117725,0.0004342731,0.0004021582,0.0001646574,0.0004201655],"domain_scores_gemma":[0.9988654,0.00009579206,0.0004373988,0.0003436501,0.000115898,0.0001418441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001832783,0.00002307613,0.000005602393,0.003577869,0.00009067538,1.855373e-7,0.00002097464,7.876965e-8,0.0003859166,0.001112766,0.0004118759,0.9943526],"study_design_scores_gemma":[0.0001862278,0.0001465551,0.000004587039,0.0006437183,0.0002036075,0.00001951872,0.00001866227,0.000007500392,0.001686835,0.00006612611,0.9967108,0.0003058652],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001480695,0.992598,0.002436247,0.0001076199,0.0001917669,0.003976222,0.0001098793,0.00002698224,0.000405224],"genre_scores_gemma":[0.0005571436,0.9891471,0.00246729,0.00007796497,0.002022516,0.003533566,0.0007597212,0.00008952463,0.001345233],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9962989,"threshold_uncertainty_score":0.9695069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06532433896495135,"score_gpt":0.3195061937847813,"score_spread":0.25418185481983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}