{"id":"W2065349703","doi":"10.3389/fonc.2013.00125","title":"Differential Roles of PML Isoforms","year":2013,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":166,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Agence Nationale de la Recherche; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Promyelocytic leukemia protein; Gene isoform; Arsenic trioxide; Acute promyelocytic leukemia; Retinoic acid; Biology; Alternative splicing; RNF4; Suppressor; Cancer research; Cell biology; Computational biology; Chemistry; Gene; Biochemistry; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006663203,0.000110816,0.0002276824,0.00006762892,0.00002248135,0.000006430894,0.0002408826,0.0002674516,0.0001273719],"category_scores_gemma":[0.00005899158,0.00009551732,0.00006489286,0.00007240869,0.0001676067,0.000004459226,0.00009355691,0.0001023182,0.00001000865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000346016,"about_ca_system_score_gemma":0.0001142358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000218628,"about_ca_topic_score_gemma":0.00001590215,"domain_scores_codex":[0.9991779,0.00005067159,0.0002477074,0.0002192341,0.00007498664,0.0002295328],"domain_scores_gemma":[0.9995899,0.000008142443,0.00009658882,0.0002036134,0.00005649484,0.00004529662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001609989,0.000285914,0.1092489,0.00008127964,0.00009041154,0.000006520981,0.0002481781,0.00004985426,0.7200407,0.0001719911,0.06750571,0.1021095],"study_design_scores_gemma":[0.002100623,0.001258422,0.01164753,0.00002416602,0.00002746919,0.00002254238,0.001225841,0.0004700017,0.8565729,0.00382609,0.1224383,0.0003861079],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.977658,0.0010619,0.01359154,0.0001132776,0.0006684979,0.0001655548,0.000003010871,0.000006442069,0.00673175],"genre_scores_gemma":[0.9931049,0.0004607369,0.005071179,0.0001084279,0.0001490934,0.00005093854,0.00004267085,0.00001388542,0.0009982047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1365322,"threshold_uncertainty_score":0.3895083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004244397088264793,"score_gpt":0.2299121546057654,"score_spread":0.2256677575175006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}