{"id":"W2065361276","doi":"10.1097/aln.0b013e3181c53849","title":"Sex-specific Mediation of Opioid-induced Hyperalgesia by the Melanocortin-1 Receptor","year":2009,"lang":"en","type":"article","venue":"Anesthesiology","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Drug Abuse; U.S. Public Health Service","keywords":"Hyperalgesia; Morphine; Medicine; Opioid; Nociception; Melanocortin; Internal medicine; Endocrinology; Receptor; μ-opioid receptor; Opioid receptor; Analgesic; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001903167,0.0001046994,0.0001855904,0.0000410254,0.0001149404,0.00001062072,0.0002859512,0.0001110789,0.0001326847],"category_scores_gemma":[0.0001083483,0.00007088458,0.0000530477,0.0001633293,0.00009705371,0.00007355455,0.00001374566,0.0001011487,0.0001201119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001228878,"about_ca_system_score_gemma":0.00002131559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008264271,"about_ca_topic_score_gemma":6.561387e-7,"domain_scores_codex":[0.9989142,0.0002250868,0.000256884,0.0002602922,0.0001569866,0.0001864827],"domain_scores_gemma":[0.9991844,0.0002912664,0.0001601907,0.000295546,0.00002869561,0.00003989329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003138559,0.0000472357,0.003192922,0.000001609053,9.944963e-7,0.000002284744,0.0002189216,0.000003890809,0.9710056,0.003829851,0.004631765,0.01703351],"study_design_scores_gemma":[0.0001741869,0.0003177437,0.1008722,0.00000290927,0.000002306873,0.00001950513,0.00002905348,0.00002328047,0.8516499,0.001668313,0.04515291,0.00008771234],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968287,0.0001128668,0.00001373531,0.001934078,0.0000956658,0.0001726931,0.0000021163,0.00004162429,0.0007985064],"genre_scores_gemma":[0.9971756,0.0002393457,0.00005890564,0.002039691,0.00009635694,0.000005452986,0.000008729615,0.000006637375,0.000369334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1193557,"threshold_uncertainty_score":0.2890589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02389971119322936,"score_gpt":0.2511117038853369,"score_spread":0.2272119926921076,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}